A COMPARATIVE STUDY ON THE EFFECTIVENESS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEIs) AND ANGIOTENSIN RECEPTOR BLOCKERS (ARBs) IN DIABETIC NEPHROPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: To observe the clinical outcomes on usage of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in type 2 diabetic nephropathy patients.Methods: A total 70 patients diagnosed with diabetic nephropathy were treated with ACEIs or ARBs were enrolled in this study. The data was collected from the out patients and the physician. A data collection form was used for collecting patient data. The form was used to record the details of patient’s demographics, history of diabetes mellitus, duration of diabetes mellitus co morbidities, food habits and laboratory parameters such as serum creatinine, HbA1c and all the relevant things. The study has obtained ethical clearance from the institution ethics committee (IEC).Results: The study showed middle aged patients were more prone to diabetes and pre-existing hypertension is a major risk factor for diabetic nephropathy. Majority of the patients had long duration of diabetes mellitus which indicates the strong relation between duration of diabetes mellitus with diabetic nephropathy. Compared to ACE inhibitors, ARBs decreased the level of renal parameters. This reveals the better reno-protective effect of ARBs over ACE inhibitors. ARBs had more beneficial effects in reducing the major risk factor like proteinuria in diabetic nephropathy. A considerable reduction in HbA1c values were also observed in patients using ARBs.Conclusion: While comparing the improvement in proteinuria and the laboratory outcomes, ARBs were beneficial relatively to the ACEs in patients with diabetic nephropathy.Â
Authors and Affiliations
N. Senthilkumar, Anandhasayanam A. , Mohammed Safil K. , Shemimol S.
Keywords
Related Articles
- EP ID EP576148
- DOI -
- Views 56
- Downloads 0
PREBIOTIC INFLUENCE OF PLANTAGO OVATA ON FREE AND MICROENCAPSULATED L. CASEI–GROWTH KINETICS, ANTIMICROBIAL ACTIVITY AND MICROCAPSULES STABILITY
Objective: To study the enhancement of antimicrobial effects of probiotic Lactobacillus casei (L. casei) both in free and immobilized form and in the presence of a natural prebiotic-Psyllium seed husk.Methods: Arabinoxyl...
ROLE OF VICIA FABA FRUIT EXTRACT AGAINST CYTOTOXICITY INDUCED BY ACETAMINOPHEN IN PRIMARY CULTURED RAT HEPATOCYTES
Objective: In the present study, Vicia faba fruit extract was screened for their hepatoprotective activity against cytotoxicity induced by acetaminophen in primary cultured rat hepatocytes.Methods: Vicia faba fruit, seed...
FORMULATION AND COMPARATIVE EVALUATION OF ONDANSETRON HYDROCHLORIDE MOUTH DISSOLVING TABLETS IN INDIA
Objective: The aim of the present study was to prepare the ondansetron hydrochloride Mouth Dissolving Tablets (MDTs) followed by its comparison with ethical and non-ethical (generic) marketed tablets. Methods: Prior to...
ENHANCED TRANSDERMAL PERMEABILITY OF TELMISARTAN BY A NOVEL NANOEMULSION GEL
Objective: Telmisartan is an angiotensin II type I receptor blocker antihypertensive agent with 42% oral bioavailability. The aim of the present investigation was to develop a nanoemulsion gel to enhance bioavailability...
SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH DOXYCYCLINE AGAINST KLEBSIELLA PNEUMONIA
Objective: Green synthesis, characterization of silver nanoparticles (AgNPs) and study of the synergistic effect of AgNPs with antibiotic doxycycline against Klebsiella pneumonia.Methods: AgNps were synthesized from bact...