A Comparative Study to Assess Effectiveness of Hemocoagulase, Tranexamic Acid and a Combination of both in Reducing Perioperative Blood Loss and Transfusion Requirement in Patients Undergoing Major Hip and Femoral Surgeries
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Major hip and femoral surgeries are often associated with significant blood loss. Aim of this clinical study, was to evaluate the efficacy of intravenous hemocoagulase, tranexamic acid and the combination of these two agents in reducing perioperative blood loss and blood transfusion requirements in these surgeries. Material and methods: 80 patients undergoing hip/femoral surgeries were randomly divided into four groups of 20 each, to receive 0.9% saline (C-control), hemocoagulase (H), tranexamic acid (T) and both agents in combination (B). The amount of perioperative blood loss, transfusion requirements and overall drainage was assessed. The hemoglobin concentration was recorded preoperatively and on postoperative day one. Results: Total perioperative blood loss in group T and group H was less by 42.9% and 50.9% compared with group C, while in group B it was reduced by 68.6%, 44.9% and 36.1% compared to group C, T and H respectively. The amount of allogenic blood transfusion in group T and group H were reduced by 64.7% and 76.5% compared to group C, while group B decreased by 94.1%, 83.3% and 75% compared to group C, T and H. Conclusion: Hemocoagulase and tranexamic acid can markedly reduce blood loss and transfusion requirements in major hip and femoral surgeries. The combination seems to achieve best results and was superior to either of the two drugs used alone. No apparent adverse events were observed.
Authors and Affiliations
Parul Gupta, Deepesh Gupta, Aditya Agarwal
Keywords
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