Icodextrin for Long Night Dwell in CAPD in Indian Patients – A Single Centre Experience
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Icodextrin is a glucose polymer derived from starch and has an average molecular weight of 20,000D. It was developed to overcome some of disadvantages of conventional dextrose solution in Continuous Ambulatory Peritoneal Dialysis (CAPD). Material and Methods: The aim of this study was to analyze the impact of Icodextrin solution on ultra-filtration, blood pressure and blood sugar levels in CAPD patients. Total number of patients in this study was 40. Results: The mean age of patients was 56.2±9.4 years with a male to female ratio of 3:1. Twenty seven of the subjects were diabetic. 9/40 (22.5%) patients were started on Icodextrin within one month of initiation on CAPD therapy while 31/40(77.5%) were initiated after one month. The reason for starting the Icodextrin was poor ultrafiltration (UF) in 18(45%), inadequate dialysis in 14 /40(35%), better blood pressure control in 44/40 (10%) and poor glycemic control in 4/40(10%) patients respectively. Mean ultrafiltration significantly increased after shifting to Icodextrin (875±450 vs. 1350±525 ml, P=0.001). There was a significant decrease in mean systolic blood pressure (139±41 Vs 128 ±38 mm of Hg, P=0.004) and diastolic blood pressure (87±10 Vs 77±8, P=0.004).The mean requirement of antihypertensive drugs was reduced from 3.5±1 to 2.0 ±0.5. The mean fasting blood sugar also decreased from 158.3±56.5 mg/dl to 132±48.6 mg/ dl while post-prandial blood sugar decreased from o mean of 256.7±103.8 mg/dl to 199.3±107.5 mg/dl. Conclusion: Icodextrin is associated with better UF, better blood pressure control, lesser need of antihypertensive drugs and better blood sugar control.
Authors and Affiliations
Amresh Krishna, Prit Pal Singh, Harsh Vardhan, R K Sharma, Amit Gupta, Narayan Prasad
Keywords
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