A Comparision of Two Different Doses of Butorphanol-Pretreatment to Establish A Minimum Effective Dose for Etomidate Induced Myoclonus - A Prospective Randomized Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Etomidate is often used for induction of general anaesthesia because of its very stable hemodynamic profile. myoclonus is common problem with induction of anaesthesia with etomidate, which may be a problem in non fasting patients, open eye injury and epileptic patients. Incidence of myoclonus shown to be reduced by variety of opioid agents. Butorphanol is strong analgesic with both narcotic agonistic and antagonistic properties. This prospective randomized study was aimed to compare two different doses of butorphanol to establish minimum effective dose for prevention of myoclonus. Material and methods: A total of 90 patients,ASA I and II undergoing elective surgery were randomized into three groups comprising of 30 patients each. Group B and Group C received butorphanol 0.04 mg/kg and 0.02 mg/kg respectively and group A received normal saline. Two minutes after pretreatment patients received etomidate 0.3 mg /kg. Assessment of myoclonus after etomidate was done using four point scale:0= no myoclonus, 1 = mild myoclonus, 2= moderate myoclonus and 3= severe myoclonus. Results: The incidence of myoclonus in Group A is 76.67% and Group B and Group C is 3.3% and 10% respectively. The difference among Group A to Group B and Group C is highly significant (P < 0.001) and Group B and Group C is statistically insignificant (P =0.296).The difference in severity of myoclonus in Group A in compared to Group B and C is statistically significant(p< 0.001) and between Group B and C is insignificant((P=0.552). Conclusion: Butorphanol 0.02 mg/kg is as effective as 0.04 mg/kg in reducing etomidate induced myoclonus.
Authors and Affiliations
Rashmi Pal, Parul Jain, K. K. Arora, Bharathi B
Keywords
Related Articles
- EP ID EP430068
- DOI -
- Views 101
- Downloads 0
To Uncover Various Factors Associated with Positive Blood Cultures amongst Neonates and Children- A Prospective Hospital based Study
Introduction: Septicemia is a serious bloodstream infection. Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life. Neo...
Evaluation of Platelet Count in Pediatric Patients with Dengue Fever: A Hospital based Study
Introduction: Dengue fever is the most frequently occurring mosquito-borne viral disease worldwide. Over the last 50 years, the incidence of dengue has increased 30-fold, with the highest rates occurring among infants. T...
Surgical Treatment of Supracondylar Femoral Fractures
Introduction: In today’s fast paced world high energy trauma is common. Supracondylar femur fractures are one of the common fractures encountered. The distal femur has wide medullary canal, thin cortex and often associat...
Esthetic Rehabilitation of a Patient with Dental Fluorosis using Porcelain Laminate Veneers - A Case Report
Introduction: Dental fluorosis is hypo-mineralization of tooth enamel caused by intake of excessive fluoride during the formative stage of enamel formation. It causes intrinsic enamel staining ranging from mild to severe...
Efficacy of Adding Dexmedetomidine to Bupivacaine on Attenuating Hemodynamic Response to Skull Pin Placement for Performing Scalp Block
Introduction: Acute increases in heart rate and arterial blood pressure can be deleterious in the neurosurgical patient with increased ICP or with cerebral aneurysms. So present study was done to evaluate the efficacy of...