A comparison of a single genetic factor, two stress factors, and one psychosocial coping factor as predictors of depression in an Australian community sample.
Journal Title: Archives of Psychiatry and Psychotherapy - Year 2014, Vol 16, Issue 4
Abstract
Aim of the studyAlthough both have shown significant effects upon depression in clinical samples, no direct comparison has been reported of the relative power of psychological resilience and the short form of the serotonin transporter gene 5-HTTLPR as predictors of depression in a community sample.Subject or material and methodsIn a sample set by a priori power analysis, 67 adult females and 59 adult males provided buccal cell samples nand responses to psychological questionaires to enable a comparison between a single genetic factor, childhood stressors, recent stressors, psychological resilience and depression.ResultsNone of genotype, childhood or recent stressors was significantly associated with depression scores, but resilience was a significant inverse predictor of depression scores and also of the presence of clinically significant depression.DiscussionAlthough power was not a limiting factor, these data are congruent with some previously reported in a major meta-analysis of the association between the 5-HTTLPR and depression.ConclusionsThese data suggest that measures of an individual’s ability to resist or recover from stress may be useful in assessing vulnerability to depression when used with ‘at risk’ individuals in everyday practice.
Authors and Affiliations
Christopher Sharpley, Suresh Palanisamy, Kate Metcalf, Kim Jones, Brian Kelly, James McFarlane
Keywords
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- EP ID EP100900
- DOI 10.12740/APP/30099
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