A Controlled, Double Blind, Prospective Study of Onset of Muscle Relaxation with Rocuronium with or without Pretreatment with Ephedrine.
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 7
Abstract
This prospective, double blind, controlled study compared the speed of onset of rocuronium with or without ephedrine. Patients aged 18-60 years, ASA grade I or II, posted for surgical procedures were allocated after a priming dose of rocuronium to either receive ephedrine (210 mcg/kg) (RE) or saline (RS) before intubation. Train of four (TOF) was checked after administration of rocuronium and time required for the disappearance of all four twitches was ascertained. Clinical parameters, time for laryngoscopy and intubating conditions were judged by blinded anaesthetists using the Cooper’s score. Mean (SD) time for the complete relaxation, time for laryngoscopy and intubating conditions (Cooper’s score) were not found to be statistically significant between RE and RS group. The Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Heart Rate (HR) were significantly higher in the RE group as compared to the RS group. Our results indicate that the benefits of using ephedrine at a dosage of 210 mcg/kg before rocuronium are not significant as compared to placebo and hence does not support the use of ephedrine before propofol-rocuronium to improve the onset of rocuronium.
Authors and Affiliations
* Dr. Naina P Dalvi, Dr. Ashwin Udupa N
Keywords
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