A Crohn’s Conundrum: Can the Faecal Calprotectin Level Act as a Sensitive Cut-off to Prevent Unnecessary MRI Small Bowel Scans?
Journal Title: Radiology – Open Journal - Year 2017, Vol 2, Issue 2
Abstract
Background: Current gastroenterology practice in evaluating those with diarrhoeal symptoms and a positive faecal calprotectin (CP) is to perform colonoscopy. Colonoscopy however is limited, in that it cannot exclude disease proximal to the terminal ileum. Therefore, for many patients not known to have Crohn’s disease, gastroenterologists are often concerned about the possibility of more proximal small bowel Crohn’s and request an magnetic resonance imaging (MRI) small bowel scan. Aims: This is the first study to investigate whether patients with a clinical suspicion of Crohn’s but with a normal colonoscopy will benefit from MRI in terms of diagnostic evaluation if they have a CP below the cut-off. Method: MRI small bowel reports, CP levels and colonoscopy reports were analysed (where obtainable) from 422 scans at a district general hospital in Stevenage, between 02/04/2015 and 21/07/2017. Eighty-five patients had features suggestive of Crohn’s but had normal colonoscopy findings. These were divided into those who had a CP above or below 600. Results: Within 55 patients who had a calprotectin below 600, we report that none (0%) of these patients were found to have significantly positive findings for Crohn’s on subsequent MRI. Amongst 30 patients with a positive CP, 8 (26.6%) were found to have active disease on MRI. The sensitivity of calprotectin was therefore identified to be 100% (95% CI 63.06% to 100%) and the specificity of the test was 71.43 % (95% CI 60% to 81.15%). Negative predictive value (NPV) was 1.00 and positive predictive value (PPV) was 0.27. Conclusion: Our study is the first to suggest that in patients with features of Crohn’s who have a normal colonoscopy, calprotectin performs impressively as a sensitive marker of the presence of small bowel inflammation on subsequent MRI. Further prospective studies would be needed to validate a potential approach of using the biomarker as a cut-off to reduce unnecessary MRI small bowel scans.
Authors and Affiliations
Faraz Hosseini-Ardehali
Keywords
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- EP ID EP554412
- DOI 10.17140/ROJ-2-117
- Views 137
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A Crohn’s Conundrum: Can the Faecal Calprotectin Level Act as a Sensitive Cut-off to Prevent Unnecessary MRI Small Bowel Scans?
Background: Current gastroenterology practice in evaluating those with diarrhoeal symptoms and a positive faecal calprotectin (CP) is to perform colonoscopy. Colonoscopy however is limited, in that it cannot exclude dise...