A cross sectional study of cutaneous adverse drug reactions with antiretroviral drugs
Journal Title: MedPulse -International Medical Journal - Year 2018, Vol 5, Issue 3
Abstract
Background: Though Highly Active Antiretroviral Therapy (HAART) which combines at least three antiretroviral (ARV) drugs is the mainstay in the management of people living with HIV/AIDS, there have been reports of adverse drug reaction. Aims: To conduct an epidemiological study on cutaneous adverse drug reactions with antiretroviral drugs. Objectives: this study was done to estimate the different cutaneous adverse drug reactions with antiretroviral drugs, age and sex distribution of reactions, their morphological patterns and its course. Materials and Methods: The prospective study was conducted among the suspected cases of HIV positive disease taking ART drugs from different ART centers in the surrounding districts and attended the Out-Patient Department of Dermatology and Venerology. All the participating patients were asked questionnaires as given in the Proforma. Relevant investigations were done. A general examination, genital, pelvic and systemic examination was performed. All the values were recorded and comparison tables were derived after statistical analysis using SPSS statistical software and the results were analyzed. Results: the study included 90 HIV positive patients taking ART drugs. It was observed that majority of the patients (71.11 %) were on ZDV+3TC+NVP regimen. 64 (71.2%) patients were females and 26 (28.8%) were males with majority of the patients (45.55 %) in 31 – 40 years age group. Majority of the patients (52.22 %) developed adverse cutaneous drug reactions between 1 to 3 weeks of onset of intake of ART. The major morphological patter observed was Morbilliform/maculopapular rash of moderate degree seen in 77.78% patients. Conclusion: The cutaneous adverse drug reactions are extremely common in HIV patients and their incidence increases with the deterioration of immunity as the disease progresses. Dermatologists should play an active role in early diagnosis of the lesion and causative agent to prevent further progression of drug reaction.
Authors and Affiliations
K Raghupathy Reddy, T Naresh Babu
Keywords
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