A Double Blind, Randomized Comparison of Intubating Conditions between Rocuronium, Atracurium and Atracurium with Priming
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Background and Aims: The present study was undertaken to evaluate and compare rocuronium, with atracurium (with and without priming dose) for the purpose of intubation with emphasis on intubating conditions, haemodynamic changes and incidence of any adverse events. Methods: This prospective, comparative randomized study was conducted at Rajindra Hospital, Patiala, Punjab. A total of 150 patients aged between 18-60 years of either sex and ASA physical status I and II scheduled for elective surgery under general anaesthesia were randomly divided into three groups as follows: Group A (n=61): Rocuronium (0.6mg/kg), Group B (n=47): Atracurium (0.7 mg/kg), Group C (n=42): priming with 0.1 mg/kg prior to second dose of Atracurium 0.6 mg/kg. Intubating conditions and hemodynamic parameters were analyzed with one way ANOVA or Chi-Square Test or Fisher's Exact Test as applicable. Results: Rocuronium produced fastest onset of apnea (48.75 ± 8.91 seconds) and for the shortest period (29.82 ± 4.64 minutes). Atracurium without priming in comparison to Atracurium with priming had delayed onset of apnea (91.45 ± 28.89 seconds versus 73.31 ± 22.58 seconds) and longer duration of action (36.34 ± 12.77 minute versus 34.38 ± 10.34 minutes) respectively. (P value < 0.001) In group A, (Rocuronium), 100% patients had acceptable intubating condition at the end of 90 seconds. The hemodynamic parameters were comparable among three groups. Anaphylactic reactions were seen with atracurium usage both with and without priming. Conclusion: Rocuronium produces the better intubating conditions compared to Atracurium with or without priming at 90 seconds and is associated with shorter duration of action.
Authors and Affiliations
Parmod Kumar, Tripat Kaur Bindra, Smruti Rekha Hota
Keywords
Related Articles
- EP ID EP534245
- DOI 10.21276/ijmrp.2018.4.4.014
- Views 92
- Downloads 0
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