Clinical Importance of Evaluation of Thyroid Function Status in Patients with Chronic Kidney Disease
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 4
Abstract
Introduction: The incidence of thyroid disorders has been found to increase with increase in the severity of renal failure. This study was carried out for evaluation of thyroid function status in patients of chronic renal failure. Methods: This case-control study was carried out at a tertiary care center. 50 cases of chronic kidney disease and 50 healthy controls were enrolled for the study. Routine laboratory investigations including blood urea and serum creatinine were done. Levels of free T3, free T4 and TSH were measured. Results: The levels of free T3 and free T4 were found to be significantly lower in patients with chronic kidney disease in comparison with healthy controls (p < 0.001, p < 0.001). On other hand, there was no significant difference in levels of TSH among the two groups (p= 0.34). There was strong negative correlation between the levels of serum creatinine and free T3 (r = -0.63, p = 0.00), and also between the levels of serum creatinine and free T4 (r = -0.49, p =0.00). Blood uea also showed a significant correlation with free T3 (r = -0.52, p = 0.00), and with free T4 (r= -0.38, p = 0.00). The levels of TSH showed insignificant relation with changes in blood urea and serum creatinine. Conclusion: This study showed that with deterioration in functional capacity of kidneys, thyroid hormone levels in circulation undergo a significant change. So evaluation of thyroid function status should be regarded as an important part of treatment in patients of chronic renal failure to achieve best results.
Authors and Affiliations
Heena Singla, Gitanjali Goyal, Neeraj Singla
Keywords
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- EP ID EP546557
- DOI 10.21276/ijmrp.2017.3.4.004
- Views 78
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