A Gout Flare Caused by the Administration of Platelet Rich Plasma: A Clinical Case
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2023, Vol 4, Issue 1
Abstract
The therapy with Platelet Rich Plasma (PRP) administered in degenerated or injured musculoskeletal tissues is a new and promising regenerative treatment option. Traditionally, it is considered that as PRP represents an autologous (to the patient) blood product, the potential for serious side effects is neglectable. Consequently, it is important that any significant negative consequences are well described. We present a fifty-five years old male patient, complaining of pain and stiffness in his right ankle joint due to multiple traumas during his earlier sport career. He had no any contraindications and PRP was injected intraarticularly under ultrasound guidance. On the next day, the patient developed an intensive pain and swelling in the regions of the right ankle and the dorsum of the right foot. The acute phase reactants were elevated and there was no leukocytosis. On ultrasound examination, there was an effusion in the tibiotalar and talonavicular joints. Arthrocentesis was performed and the microscopic examination revealed the typical needle shaped monosodium urate crystals inside the joint fluid and no bacteria. Consequently, the diagnosis of acute gouty flare was made (the patient has a history of gout, but did not have any flares in the past two years). As PRP concentrate contains naturally many proinflammatory molecules, we speculate that some of them may activate the macrophages that residue normally in the synovium and the capsule of the injected joint. The activated macrophages further may react to the MSU crystals deposited there, leading to the development of a gouty flare. In conclusion, the possibility of a flare should be explained to gouty patients, candidate for PRP treatment.
Authors and Affiliations
Plamen Todorov, Anastas Batalov
Keywords
Related Articles
- EP ID EP713571
- DOI https://doi.org/10.46889/JRMBR.2023.4103
- Views 28
- Downloads 0
The Applications of Human Umbilical Cord Mesenchymal Stem Cells to Treat Spinal Cord Injuries
Due to the morbidity and resulting lifestyle changes of Spinal Cord Injuries (SCI), there has been an extensive need to evaluate potential treatments. Mesenchymal cells hold the capacity to address both the primary and s...
Stem Cell Therapies in Systemic Sclerosis: An Updated Review
Systemic sclerosis systemic is a systemic autoimmune disease that ultimately leads to severe damage and failure of multiple body organs. The disease is associated with significant morbidity and mortality as well as poo...
Patch Repair for Intestinal Perforation Closure in an Ex-Vivo Porcine Model with Burst Pressure Characterization
Background: Bowel perforation is the loss of intestinal wall integrity and can occur by several mechanisms including infection, obstruction, inflammation, trauma and iatrogenic causes. Incidences of bowel perforation ran...
Stem Cell Treatment for Acute Lymphoblastic Leukemia in Adults
Stem cell therapy used to treat Acute Lymphoblastic Leukemia in adults (ALL) has been one of the more promising uses of stem cells and has large implications on the survival rate of adults with ALL. While the survival ra...
The Jounced Entrails-Intestine in COVID-19
Coronavirus disease 2019 (COVID-19), initiated by contemporary coronavirus is a pandemic which engenders severe respiratory disease. SARS-CoV-2 preponderantly transmits through airborne particles and mammoth respirator...