A LOCALLY SYNTHESIZED PROBIOTIC FOR MAINTAINING IMMUNE SYSTEM FUNCTIONS IN IMMUNOCOMPROMISED NZW RABBITS

Apply

A LOCALLY SYNTHESIZED PROBIOTIC FOR MAINTAINING IMMUNE SYSTEM FUNCTIONS IN IMMUNOCOMPROMISED NZW RABBITS

Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 6

Abstract

This study aimed to develop a novel probiotic, using microorganisms isolated and identified from rabbit‟s colon, for developing a nutritional supplement to maintain and treat the weaken immune system responses in immunocompromised animals. 30 NZW rabbits divided into three groups, the first served as a control, while the other two were induced with Azathioprine (20mg\kg\Day) for two weeks to make them immunocompromised, one of them treated with the probiotic and the other group has left to heal naturally, both were monitored for another two weeks as treatment or healing period. Results indicated that treatment with this probiotic enhanced effectively the immunocompromised rabbits, an improvement of full blood count has indicated in the treated group (5.42±2.20 x109), whereas the non-treated group was (3.20±0.59 x109), compared to control group (9.68±0.30 x109). A significant decrease recorded in lymphocytes percentage of rabbits treated with probiotic (25%), and non-treated (20%) compared to control (66%). Monocytes count has been higher in immunocompromised groups, treated and non-treated (10% and 12% respectively) compared to control (5%). Neutrophils count showed less percentage in non-treated (3%) and treated (2%) compared to control group (23%). These findings declared that the daily uptake of this probiotic has improved significantly the specific and nonspecific immunity of impaired rabbits, caused by the immunosuppressive drug. The study implicated the use of this product could be a basis for further studies to develop a promising commercial product for reducing medical complications caused by an immunosuppressant given to human patients or domesticated animals under certain conditions.

Authors and Affiliations

Dr. Imad Dawood Saleh

Keywords

RAPID AND SPECIFIC DIAGNOSIS OF BACTERIAL SEPSIS IN HIGH RISK PATIENTS

Sepsis is a major healthcare problem worldwide, athe accurate and timely detection of sepsis remains a challenge specially in high risk patients as blood culture and sensitivity testing results are slow and delay the beg...

DEVELOPMENT AND VALIDATION OF A SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF ATORVASTATIN IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)

A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. Th...

EP ID EP618223
DOI -
Views 151
Downloads 0