A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis
Journal Title: Meandros Medical and Dental Journal - Year 2018, Vol 19, Issue 3
Abstract
Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder. The control and study groups were compared with respect to native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios. The relationships between demographic and lesion characteristics, native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were studied. Results: The mean age of AA patients was 37.5 years. Fifty-eight (58%) patients were male, and the median body mass index was 24 kg/m2. Median age was significantly higher in the AA group (p<0.05). The AA group had a significantly lower total and native thiol level, native thiol/total thiol ratio, significantly higher disulphide level, disulphide/native thiol ratio, and disulphide/total thiol ratio (p<0.05 for all comparisons). There was no correlation between the parameters of thiol/disulfide hemostasis and demographic and lesion characteristics (p>0.05). Conclusion: The thiol/disulphide homeostasis shifted towards oxidative stress, and a decrease in thiols and an increase in disulphides were found in the AA patients. This finding may be responsible for diffuse destruction of hair follicle in the pathogenesis of AA.
Authors and Affiliations
Suzan Demir Pektaş, Emine Tuğba Alataş, Gürsoy Doğan, Salim Neşelioğlu, Özcan Erel
Keywords
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- EP ID EP399344
- DOI 10.4274/meandros.48303
- Views 96
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