A META-ANALYSIS STUDY OF POLYCHEMOTHERAPY VERSUS MONOCHEMOTHERAPY IN PATIENTS OF METASTATIC BREAST CANCER
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 3
Abstract
Polychemotherapy and intermittent monochemotherapy regimens in metastatic breast cancer were examined in a meta analysis that included both tumor response rate and toxicities. Randomized controlled studies (conducted during 1990-2008) comparing monochemotherapy and poly-chemotherapy in advanced breast cancer patients were selected from electronic databases. Meta-analysis for response rate and toxicities [nausea and vomiting, toxic death, alopecia and reduced white cell count (WCC)] was performed using the Mantel-Haenszel method. The heterogeneity among the trials was assessed through a χ2 statistic, I2 and visual inspection of the forest plots. Analysis of eligible studies reveals statistical significant difference in response rate (OR 0.72, 95% CI 0.65-0.79), nausea and vomiting (OR 0.80, 95% CI 0.67-0.59), Alopecia (OR 0.75, 95% CI 0.64-0.88) and reduced WCC (OR 0.55, 95% CI 0.48-0.62) which favours polychemotherapy except toxic death (OR 0.87, 95% CI 0.58-1.29). There was marked evidence of heterogeneity in all end points except toxic death. This meta analysis shows the superiority of efficacy but not of safety of polychemotherapy over that of a single agent. However, the choice of treatment should be based on the response to the therapy, toxicity, patient preference, presence of metastases or imminent complications requiring aggressive and rapid tumor control.
Authors and Affiliations
Amal Kumar, Bhaswat S. Chakraborty
Keywords
Related Articles
- EP ID EP625171
- DOI 10.25004/IJPSDR.2016.080302
- Views 69
- Downloads 0
Antipsychotic Prescribing Pattern in Elderly Patients with Psychiatric Disorders
The elderly people are more prone to develop psychiatric disorders due to a number of factors like changes in the brain, other illnesses etc. They represent the most vulnerable group as they are most sensitive to the eff...
EVALUATION OF HEAVY METAL DISTRIBUTION AND ANTIBACTERIAL ACTIVITIES OF MEDICINAL PLANTS TINOSPORA CORDIFOLIA, OCIMUM SANCTUM AND PIPER NIGRUM
To evaluate the inhibition and the in vitro interaction of the pathogens with the plant extracts, various solvent extracts of Tinospora cordifolia, Ocimum sanctum, Piper nigrum were screened for antimicrobial activity us...
DEVELOPMENT AND CHARACTERIZATION OF ALGINATE MICROSPHERES CONTAINING OLMESARTAN BY IONOTROPIC GELATION METHOD
The present study was designed to formulate and evaluate the Olmesartan sodium alginate microspheres. Fourteen formulations batches of microspheres (S1-S14) were prepared by using ionotropic gelation method. Sodium algin...
FORMULATION AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF ACECLOFENAC BY USING SUBLIMATION METHOD
In the present work, fast disintegrating tablets of Aceclofenac were prepared by subliming method with a view to enhance patient compliance. In this paper, two super-disintegrants, viz., crospovidone and sodium starch gl...
COMPUTATIONAL STUDIES OF SYNTHETIC AND PLANT-DERIVED COMPOUNDS AGAINST CARDIOVASCULAR DISEASE TARGETS
Knowledge of cardiovascular diseases and improved diagnostic capacity is rapidly expanding with the advancement of medical sciences. However, heart diseases are a challenge to human life. Few important therapeutic target...