SYNTHESIS AND ANTIMICROBIAL SCREENING OF NEW PYRAZOLINES DERIVED FROM CHALCONES OF VANILLIN ANALOG
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 2
Abstract
In present study the new series of 3-(Aryl)-5-[4-(2, 4-Dichlorophenylmethoxy)-3-methoxyphenyl]-4, 5-dihydro pyrazoline (2a-k) and 3-(Aryl)-5-[4-(2, 4-Dichlorophenylmethoxy)-3-methoxyphenyl]-4, 5-dihydroacetyl pyrazoline (3a-k) derivatives were synthesized from various substituted 3-Methoxy-4-(2, 4-Dichlorophenyl methoxy) chalcones (1a-k). The new chalcones were synthesized using various acetophenones with newly synthesized aldehyde of vanillin analog by Claisen-Schmidt condensation. Characterization of pyrazoline derivatives have been established on the basis of IR, NMR, Mass and elemental analyses. The derivatives were screened for their in vitro antimicrobial Screening.
Authors and Affiliations
Krushnkumar Karangiya, Jatin Upadhyay
Keywords
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- EP ID EP625155
- DOI 10.25004/IJPSDR.2016.080206
- Views 87
- Downloads 0
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