FORMULATION AND IN-VITRO EVALUATION OF POLYHERBAL MICRO-EMULGEL CONTAINING TINOSPORA CORDIFOLIA AND CURCUMIN FOR TREATMENT OF ARTHRITIS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 5
Abstract
Arthritis is the condition which is associated with inflammation of a joint, pain, swelling, and stiffness. Drug delivery to the target site remains a challenge due to ineffective drug delivery system. An attempt has been made to formulate and evaluate micro-emulgel for the effective drug delivery in the treatment of Arthritis. Micro-emulgel was loaded with Curcumin and Tinospora cordifolia to enhance bioavailability of extracts which have been widely used in the treatment of arthritis. Micro-emulgel was prepared by emulsion-solvent diffusion method using carbopol 940P as a gelling agent. Micro-emulsion was formulated using Liquid paraffin oil as oil phase; Tween 80 and Span 20 as surfactant and co-surfactant respectively. FTIR studies proved the compatibility between drug, excipient and carbopol. The Prepared micro-emulgel was subjected to various parameters such as pH, rheological studies, spreadability, thermodynamic stability tests, drug content, electro conductivity, and in-vitro release studies. The pH of all formulations was found near to the skin pH value. Viscosity and spreadability of F1 optimized formulation was found to be 146.5×103 cPs and 2.24 g×cm. From the in vitro drug release study, it was revealed that sustained release of formulation last up to 18 hours. F1 formulation showed the highest drug release of Curcumin (92.37%) and Tinospora cordifolia (90.75%). SEM images showed the diameter of oil globules of Micro-emulgel were in range of 1.50 to 2.13µm. Drug release kinetics showed the zero order drug release from the optimized F1 formulation. From the stability studies, F1 formulations had an excellent physical stability.
Authors and Affiliations
Susheel Thakur, Nisha Thakur, Niladry Shekar Ghosh
Keywords
Related Articles
- EP ID EP625199
- DOI 10.25004/IJPSDR.2016.080504
- Views 93
- Downloads 0
UV-SPECTROPHOTOMETRIC DETERMINATION OF NATEGLINIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM USING HYDROTROPIC SOLUBILIZATION TECHNIQUE
Nateglinide is practically insoluble in water, sparingly soluble in strong acid; soluble in strong bases. It is an anti-diabetic, effective in treatment of diabetes. Solubility of Nateglinide is increased by using 0.1M P...
DESIGN AND SYNTHESIS OF 7-CHLORO-3-SUBSTITUTED QUINAZOLIN-4(3H)-ONES AS POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC AGENTS
In our effort to identify potent anti-inflammatory and analgesic agents a number of 7-chloro-3-substituted-2-phenylquinazolin-4(3H)-ones have been synthesized starting from 4-chloro anthranilic acid. Docking analysis of...
SELECTIVE CYTOTOXIC ACTIVITY OF SYNTHETIC NATURAL CYCLOPEPTIDES ON HCT11 & B16F10 CELLS
Peptides are natural messenger molecules of human body and hence ideal lead compounds for the initiation of drug discovery research. They are the important organic compounds with potent biological activities. Peptides fu...
IDENTIFICATION OF NOVEL GLYCOGEN SYNTHASE KINASE-3Β INHIBITOR THROUGH COMBINED SHAPE-BASED SCREENING AND MOLECULAR DOCKING APPROACH
Glycogen synthase kinase-3β (GSK-3β) is an important class of therapeutic drug target currently receiving wide attention. In our computational approach, shape-based similarity search was used to screen the SPECS database...
ANTIMICROBIAL ACTIVITY OF WHOLE FRUITING BODIES OF TRAMETES HIRSUTA (WULF. FR.) PIL. AGAINST SOME COMMON PATHOGENIC BACTERIA AND FUNGUS
Aqueous and methanolic extracts of fruit bodies of Trametes hirsuta were tested against five pathogenic fungi like Penicillium sps., Aspergillus fumigatous, Aspergillus niger, Aspergillus flavus and Mucour indicus and fi...