A Multi Marker Evaluation of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Background: Rheumatoid arthritis (RA), an inflammatory joint disease, is also associated with systemic effects. Patients with RA have an increased risk of morbidity and mortality that is mainly attributable to cardiovascular disease (CVD). Both traditional and novel risk factors are implicated in causing the increased CVD risk in RA patients. Materials and Method: Forty six RA patients, diagnosed with RA as per 1987 revised ARA criteria and forty six age and sex matched healthy controls were studied. Fasting lipid profile (Total cholesterol, triglycerides, HDL cholesterol), inflammatory markers (high sensitivity C reactive protein [hsCRP] and fibrinogen), oxidant and antioxidant markers (malondialdehyde [MDA] and ferric reducing ability of plasma [FRAP]), uric acid, homocysteine and Nitric oxide (NO) were measured in all subjects. Results: Among the traditional lipid parameters studied, triglycerides were increased in RA patients compared to controls (p=0.023). Both hsCRP (p<0.001) and fibrinogen (p=0.006) were elevated in RA patients than in controls. MDA levels were increased (p<0.001) and FRAP levels decreased (p<0.001) in patients with RA compared to controls. Uric acid and homocysteine levels showed no significant difference between RA patients and controls. Nitric oxide levels were increased in RA patients when compared with controls (p=0.030). Conclusion: Patients with rheumatoid arthritis were found to have an increased risk of CVD as evidenced by increased triglyceride levels, increased inflammatory markers, presence of oxidative stress. Hence, management of these patients should also include evaluation of CVD risk besides treatment of joint symptoms.
Authors and Affiliations
Krishna Barla, Kiranmayi S. Vinapamula, Siddhartha kumar Bhattaram, Aparna R. Bitla, Suchitra M. Manohar
Keywords
Related Articles
- EP ID EP296818
- DOI 10.18231/2394-6377.2017.0033
- Views 76
- Downloads 0
Assessment of Lipoprotein (a) and Lipid Profile Pattern in patients of Pre-Eclampsia
Introduction: Preeclampsia is a hypertensive disorder of pregnancy characterized by endothelial dysfunction. The present study was planned to assess and compare the levels of serum Lipoprotein (a) and lipid profile in pr...
Comparative study of oxidative stress in type 2 diabetes mellitus with in vitro oxidative stress using ferrous ascorbate as pro-oxidant
Diabetes mellitus is a chronic endocrine disorder associated with a multitude of microvascular and macrovascular complications The imbalance between the productions of free radicals plays a prominent role in the developm...
Impact of Calibration of pipette on Quality Control Results
Background: Majority of biochemical investigations requires pipette for delivery of reagents and samples in clinical laboratory so that pipette that is used for the same must be properly calibrated for accurate results....
Use of dried blood spot as an alternative method to estimate serum triglyceride in field studies
Introduction: Cardiovascular diseases are showing an increasing trend in both developing as well as developed countries. Raised triglycerides is considered as an important risk factor of cardio vascular diseases. Collect...
Obesity, obesity related hypertension, their association with adipocytokines among 12-16 years school students
Obesity, obesity related hypertension is increasing at higher rates among adolescents these days. An increase in leptin level and a decrease in adiponectin level were observed in obese individuals with hypertension. Our...