A New Method Development and Validation for Quantitative Estimation of Olmesartan Medoxomil in Pharmaceutical Dosage form by UV
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 3
Abstract
A Simple, Sensitive,Precise,Accurate and Linear Spectroscopic Method has been Developed and Validated for the Estimation of Olmesartan Medoxomil in Tablet Dosage form. The λmax of Olmesartan Medoxomil was Determined by using Acetonitrile : Methanol(1:1) as Solvent and Absorption Maxima of Olmesartan was found to be 257nm.The Linearity was obtained in the Range of 5-15 ug/mL and Coefficient of Correlation was found to be 0.9997.The %RSD was found to be below 2.0 for Repeatability and Interday Precision indicated that the Method was highly Precise. The LOD and LOQ were found to be 0.26 & 0.8ug/ml revealed that the method was Sensitive. The percentage recovery value was found to be 100.12% to 101.87 %, indicating the accuracy of the method and absence of interference of the excipients present in the formulation. The proposed method was simple, fast, Specific, accurate, precise, Rugged and reproducible and hence can be applied for routine quality control analysis of Olmesartan Medoxomil pharmaceutical formulations. Keywords: Olmesartan, UV Spectroscopy, Estimation, Validation.
Authors and Affiliations
M. Vijayakumari ,, K. Prasadbabu ,, K. Lakshmi Prasanna, M. Prathap ,
Keywords
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