A new thiosemicarbazide ligand chelate with CuCl2 prompt C-N coupling reaction
Journal Title: Science Paper Online - Year 2010, Vol 5, Issue 3
Abstract
A new methodology for Copper-catalyzed coupling reaction has been developed, in which imidazole reacts with aryl halides using the combination of 1-(4-hydroxy-3-me thoxybenzylidene) thiosemi-carbazide (L1) and CuCl2 as catalyst system. The most important point is to first use the new ligand L1 combining with Copper (Ⅱ) catalysts to perform better catalytic effect than that of Copper (Ⅰ) catalysts. Due to the stability and economy of Copper (Ⅱ), the methodology is a promising approach to prepare N- arylation of imidazoles. In addition, the catalysis system has been optimized, and another compounds have been synthesized base on the same method. Finally, compounds 3a~3h were confirmed by 1HNMR.
Authors and Affiliations
Xiaolei Jia, Jiannan Xiang
Keywords
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