A NON-RANDOMISED, COMPARATIVE CROSS-SECTIONAL STUDY TO ANALYSE THE SIGNIFICANCE OF ‘PRESSURE-TO-CORNEA INDEX’ IN PSEUDOEXFOLIATION EYES WITH AND WITHOUT CLINICAL GLAUCOMA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 2
Abstract
BACKGROUND Pseudoexfoliation syndrome is an age-related systemic disease manifesting itself primarily in the eyes and is characterised by the accumulation of microscopic granular amyloid-like protein fibres. Pseudoexfoliation is the most commonly seen identifiable cause of secondary glaucoma. The significance is that, it has a more aggressive clinical course with higher IOP readings and is difficult to treat due to poor response to medications. Aim- To find out the distribution of PCI in patients with Pseudoexfoliation (PXF) and to find out whether PCI can be taken as a predictor for clinical open angle glaucoma (OAG) secondary to pseudoexfoliation. MATERIALS AND METHODS Ours was a non-randomised, cross-sectional observational study conducted over a period of 6 months among 112 eyes of patients above 40 years of age with pseudoexfoliation. The eyes were categorised into the following 4 groups: Group 1- Pseudoexfoliation syndrome; Group 2 - Eyes with pseudoexfoliation with normal corrected IOP but with glaucomatous disc and visual field changes; Group 3 - Eyes with pseudoexfoliation with raised IOP, but with normal disc and visual field; Group 4 - Pseudoexfoliative glaucoma. All the statistical analysis was done using statistical software IBM SPSS Ver. 21.0 (Armonk, NY). RESULTS 49 eyes PXS as Group 1, 19 eyes in group 2, 16 eyes in group 3 and 28 eyes in Group 4. Kruskal-Wallis test was used to compare the IOP, CCT and PCI measurements between the groups - P value is <0.001 which is statistically significant. The mean, SD and range in non-glaucomatous and glaucomatous eyes were compared using Rank sum, Mann-Whitney U test - P value <0.001 is statistically significant. This study shows that PCI can differentiate between glaucomatous and non-glaucomatous eyes better than the IOP levels in eyes with Pseudoexfoliation. This can be highly helpful in PXS patients with high PCI, to have a close followup schedule and for early diagnosis and treatment of pseudoexfoliative glaucoma, so that further damage to optic nerve head can be prevented. CONCLUSION Increased PCI values in PXG patients can more accurately indicate the severity of glaucoma.
Authors and Affiliations
Anbazhaghan Amudha, Essakki Rajeswari, Srinivasan Muralikrishnan, Ponnambalam Arunkumar, Devaraj Manoj, Bohar Sugapriya, Shanmugam Rajeswari
Keywords
Related Articles
- EP ID EP284568
- DOI 10.14260/jemds/2018/52
- Views 77
- Downloads 0
A SEROPREVALENCE SURVEY OF COMMON VIRAL INFECTIONS AMONG SUSPECTED CASES ATTENDING TERTIARY CARE HOSPITAL IN AMRITSAR DISTRICT OF PUNJAB, INDIA
BACKGROUND Timely identification of an epidemic occurrence and appropriate strategies for treatment require accurate diagnosis of viral diseases. However, the data for incidences of viral diseases in the northern parts o...
HISTOPATHOLOGICAL CHANGES OF FALLOPIAN TUBE IN UTERINE MALIGNANCIES
BACKGROUND Malignant neoplasms of uterus account for significant proportion of all female cancers, though rare in India compared to Western countries. Extrauterine involvement has a significant effect on prognosis and tr...
DISSEMINATED ASPERGILLOSIS IN AN AUTOPSY CASE OF YOUNG MALE
Aspergillus is a ubiquitous mold that causes allergies (allergic bronchopulmonary aspergillosis) in otherwise healthy people and serious sinusitis, pneumonia and invasive disease in immuno-compromised individu...
CHARACTERISATION AND ANTIFUNGAL SUSCEPTIBILITY TESTING OF CANDIDA SPECIES ISOLATED FROM CLINICAL SAMPLES OF PATIENTS ATTENDING KATIHAR MEDICAL COLLEGE, KATIHAR, BIHAR
BACKGROUND Of the various candida species, more than 90% of invasive infections are caused by Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida dubliniensis and Candida...
SEPARATED INSTRUMENTS- A MIND-SET BETWEEN HARD AND ROCK- A REVIEW
BACKGROUND With an increased practice of rotary endodontics in recent years separated rotary nickel-titanium (NiTi) files in root canals is the most commonly reported mishap, causing lot of stress and anxiety among clini...