A NON-RANDOMISED, COMPARATIVE CROSS-SECTIONAL STUDY TO ANALYSE THE SIGNIFICANCE OF ‘PRESSURE-TO-CORNEA INDEX’ IN PSEUDOEXFOLIATION EYES WITH AND WITHOUT CLINICAL GLAUCOMA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 2
Abstract
BACKGROUND Pseudoexfoliation syndrome is an age-related systemic disease manifesting itself primarily in the eyes and is characterised by the accumulation of microscopic granular amyloid-like protein fibres. Pseudoexfoliation is the most commonly seen identifiable cause of secondary glaucoma. The significance is that, it has a more aggressive clinical course with higher IOP readings and is difficult to treat due to poor response to medications. Aim- To find out the distribution of PCI in patients with Pseudoexfoliation (PXF) and to find out whether PCI can be taken as a predictor for clinical open angle glaucoma (OAG) secondary to pseudoexfoliation. MATERIALS AND METHODS Ours was a non-randomised, cross-sectional observational study conducted over a period of 6 months among 112 eyes of patients above 40 years of age with pseudoexfoliation. The eyes were categorised into the following 4 groups: Group 1- Pseudoexfoliation syndrome; Group 2 - Eyes with pseudoexfoliation with normal corrected IOP but with glaucomatous disc and visual field changes; Group 3 - Eyes with pseudoexfoliation with raised IOP, but with normal disc and visual field; Group 4 - Pseudoexfoliative glaucoma. All the statistical analysis was done using statistical software IBM SPSS Ver. 21.0 (Armonk, NY). RESULTS 49 eyes PXS as Group 1, 19 eyes in group 2, 16 eyes in group 3 and 28 eyes in Group 4. Kruskal-Wallis test was used to compare the IOP, CCT and PCI measurements between the groups - P value is <0.001 which is statistically significant. The mean, SD and range in non-glaucomatous and glaucomatous eyes were compared using Rank sum, Mann-Whitney U test - P value <0.001 is statistically significant. This study shows that PCI can differentiate between glaucomatous and non-glaucomatous eyes better than the IOP levels in eyes with Pseudoexfoliation. This can be highly helpful in PXS patients with high PCI, to have a close followup schedule and for early diagnosis and treatment of pseudoexfoliative glaucoma, so that further damage to optic nerve head can be prevented. CONCLUSION Increased PCI values in PXG patients can more accurately indicate the severity of glaucoma.
Authors and Affiliations
Anbazhaghan Amudha, Essakki Rajeswari, Srinivasan Muralikrishnan, Ponnambalam Arunkumar, Devaraj Manoj, Bohar Sugapriya, Shanmugam Rajeswari
Keywords
Related Articles
- EP ID EP284568
- DOI 10.14260/jemds/2018/52
- Views 92
- Downloads 0
URINARY TRACT INFECTION, ITS CAUSATIVE MICROORGANISMS AND ANTIMICROBIAL SUSCEPTIBILITY OF ENTEROBACTERIACEAE ISOLATES IN AND AROUND PARBHANI
BACKGROUND Urinary tract infection (UTI) remains a major public health problem and occurs in all populations and age groups. However, urinary tract infection is fourteen times more common in females than males, especiall...
A RARE CASE OF CENTRAL RETINAL VEIN OCCLUSION WITH CILIORETINAL ARTERY OBSTRUCTION IN A YOUNG FEMALE-A CASE REPORT
The association of cilioretinal artery occlusion with central retinal vein occlusion is very rare and not commonly seen in elderly. The so far reported cases are commonly seen in males. • The pathogenesis of...
STUDY OF PREVALENCE AND MORPHOLOGICAL PATTERNS OF ANAEMIA IN ADULT AND GERIATRIC POPULATION: A HOSPITAL-BASED STUDY
BACKGROUND Literature reviews suggest that elderly are susceptible to severe complication due to anaemia compared to the younger ones. WHO defines that male <13 g/dL and female <12 g/dL should be termed as...
FURCAL OBLITERATION FOR ADVANCED FURCATION INVASIONS USING GLASS – IONOMER RESTORATIVE MATERIAL
Periodontal disease involving the furcation of multi-rooted tooth often complicates the treatment and prognosis of the affected tooth. Multiple modalities have been utilized over the years with unpredictable success. Cla...
ROLE OF CEREBROPROTEIN HYDROLYSATE IN OUTCOME AND RECOVERY OF TRAUMATIC BRAIN INJURY
BACKGROUND Traumatic Brain Injury (TBI) is a complex injury with a wide range of symptoms and disabilities, which can lead to a lifelong devastating effect on the patient and the family. Its (TBI) incident is increasing...