A Novel Formulations For Solubility Enhancement Of Sparingly Water-Soluble Drug Using Solvent Evaporation Method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) characterized by poorly water solubility, which influences negatively on the bioavailability. This research aims to improve the solubility of phenylbutazone by incorporating with two different types of silica at various surface area and pore size. It will also explore the effect of different ratios of silica on dissolution profiles. Phenylbutazoneformulated with silicas were prepared using a solvent evaporating method, and the impregnated carriers characterized using XRD, Digital Microscopy, and particle size distribution analysis. There was a significant enhancement of drug release for all formulated products compared with the dissolution profile of pure drug. This enhancement can be ascribed to a large surface area of porous silica and improved wettability. Mesoporous silica SP 53D-11785 provided the highest drug release in comparison with silica gel, and this may be due to its capacity and also large internal pore volume, of silica SPD for greater loading with the drug because it has a highly accessible pore network.
Authors and Affiliations
Abdullahi A. Shamsuddeen, Usman Jamilu1, Faraj Muhammad2 ,, Mustapha G. Sulaiman
Keywords
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- EP ID EP384564
- DOI 10.9790/3008-1103032835
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