Plasmodium Falciparum Clearance in Malaria Treated Children at Lake Alau Settlements, North Eastern Nigeria: Effects of Body Weight
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 4
Abstract
The influence of body weights on Plasmodium falcifarum clearance in malaria positive children was conducted using AT+SP and AQ+SP combination therapies, at the malaria holo – endemic and risk settlements of lake - alau, North Eastern Nigeria. A total of 313 children (6 - 59 months) were admitted into the study, to assess the efficacies of the combination therapies in children (6 - 59 months) using the effects of Body weights (kg) on parasite densities. Each child’s weight was determined on days 0, 1, 2, 3, 4, 7, 14 and 28 during the follow up periods. The drugs were administered between 0-3 days. Finger prick and venipuncture (syringe) techniques were employed and blood was sampled by pricking using sterilized needle on days 0, 1, 2, 3, 4, 7, 14 and 28 for the assessment of parasite densities count (per µl) while blood smear was prepared using Giemsa stained slides making thick and thin blood smears. The result shows body weight exerted negative effects on Plasmodium falciparum between the range of 71.63 to 96.0% for AT+SP and 87.79 to 96.38% for AQ+SP in the first three days of treatment. Furthermore, results showed for each kg gain in body weight there was a synchronous parasite clearance by 325.79 versus 1199.91∕µ, 16.621 versus 157.06∕µ, 17.445 versus 153.5∕µ for AT+SP versus AQ+SP on days 1, 2, and 3, respectively. The terminal resultsindicated a higher residual parasitaemia at the onset of late phase in children treated with AQ+SP (195.17 to 113.92∕µ) tcompared to AT+SP (182.48 to 25.531∕µ). The respective parasite densities clearance per kg body weight for days 7, 14 and 28 for AT+SP versus AQ+SP was 33.82 versus 35.887∕µ, 10.076 versus 29.578∕µ and 2.3548 versus 26.368∕µ respectively. Thus, on each of the late follow-up days, the rate of parasite depletion was higher in AQ+SP than AT+SP.*Corresponding Author: muskokoss@gmail.com
Authors and Affiliations
M. Kokori1 ,, M. G. Babakura, 2, U. N. Gadzama, A. Abba T
Keywords
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