A NOVEL NON–RECEPTOR AND NON- GABAERGIC ANTIANXIETY-LIKE ACTIVITY OF FORSKOLIN: SYNERGY WITH DIAZEPAM

Abstract

Objective: Clinical problems associated with the benzodiazepines like dependence, withdrawal or tolerance may lead to under use of substances based on gamma-amino butyric acid (GABA). Non-GABAergic and substances that elevate cyclic adenosine monophosphate (cAMP) have shown anti-anxiety activity. Therefore, present investigation aimed to explore a non-GABAergic mechanism and non-receptor mediated anti-anxiety activity of a cAMP elevating agent, forskolin.Methods: Elevated plus maze and light/dark box were employed to measure effect of forskolin on anxiety and the noted activity was compared with that of diazepam. cAMP levels were also measured in plasma of mice.Results: Forskolin produced a significant antianxiety- like activity in unstressed mice and stressed mice. Diazepam produced a significant antianxiety- like activity in unstressed mice but not in stressed mice. The noted antianxiety activity of forskolin was accompanied by a significant elevation of cAMP levels.Conclusions: The present findings contribute to suggest a non– receptor mediated anti-anxiety action of a forskolin, acting through cAMP elevation, thus avoiding receptor-mediated adverse effect profile of the conventional anxiolytics. 

Authors and Affiliations

Ritu Malik, Neeraj Gilhotra

Keywords

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  • EP ID EP579063
  • DOI -
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How To Cite

Ritu Malik, Neeraj Gilhotra (2015). A NOVEL NON–RECEPTOR AND NON- GABAERGIC ANTIANXIETY-LIKE ACTIVITY OF FORSKOLIN: SYNERGY WITH DIAZEPAM. International Journal of Pharmacy and Pharmaceutical Sciences, 7(2), 200-203. https://europub.co.uk/articles/-A-579063