A NOVEL SYNTHESIS OF CEFIXIME FROM 7-AMINO-3-VINYL CEPHALOSPORANIC ACID (7-AVCA)
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 1
Abstract
The present invention relates to simple and easy process for the preparation of cefixime. 7-amino-3-vinyl cephalosporanic acid (7-AVCA) is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(3-aminothiazol-4-yl)-2-(methoxy carbonyl)-methoxyimino acetate (MICE) in tetrahydrofuran and water mixture at 0-4oC in the presence of triethanolamine. The novel feature of this study was the use of triethanolamine replaced triethylamine in the activation reaction between 7-AVCA with MICE. The results showed that, cefixime has high purity (HPLC purity: 97%) and total yield 66% in the reaction time of 1.5 hours (less than 30 minutes with previous process).
Authors and Affiliations
Doan Ngoc Nhuan
Keywords
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