A NOVEL TECHNIQUE TO ENHANCING THE SOLUBILITY AND DISSOLUTION OF KETOPROFEN USING FREEZE DRYING
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
The aim of the present work was to develop a ketoprofen freeze dried tablet (FDT). Which dissolve instantaneously in the mouth. The solubility and dissolution rate of poorly water-soluble ketoprofen was improved by preparing a FDT of ketoprofen using freeze-drying technique. The FDT was prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatin, lysine, and sorbitol. The mixture was poured in to the pockets of blister packs and then was subjected to freezing and lyophilization. The FDT was characterized by DSC, XRD and SEM and was evaluated for saturation solubility and dissolution and compared with physical mixture (PM) and pure drug. The samples were stored in stability chamber to investigate their physical stability for 90 days. Result obtained by DSC and X-ray studied showed that Crystalline state of ketoprofen in FDT transformation to amorphous state during the formation of FDT. SEM result suggests reduction in ketoprofen particle size. The solubility of ketoprofen from the FDT showed six and half times greater than pure drug was due to super-saturation generated by amorphous form of the drug. Dissolution studies showed that dissolution rate of FDT of ketoprofen significantly improved compared with the PM and the pure drug. More than 90% of ketoprofen in FDT dissolved within 5 min. compared to only 29.21% of ketoprofen pure drug dissolved during 60 min. In stability test, the dissolution release profile of the ketoprofen in FDT was almost unchanged as compared with the freshly prepared FDT.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Selvam Panner
Keywords
Related Articles
- EP ID EP150710
- DOI -
- Views 99
- Downloads 0
CYTOTOXIC ACTIVITY OF AVOCADO SEEDS EXTRACTS (Persea americana MILL.) ON T47D CELL LINES
Avocado (Persea americana Mill.) is a widely grown plant that had been studied for several activities such as antioxidant and chemopreventive. The aims of this study were to analyze the secondary metabolite compounds con...
SYNTHESIS AND BIOLOGICAL EVALUATION OF (E)-3-(2-(4-SUBSTITUTEDPHENYL)-1H-INDOLE-3-YL)-(4-SUBSTITUTEDPHENYL) PROP-2-EN-1-ONE AS ANTI-INFLAMMATORY AGENTS
The reaction of 2-aryl-1H-indole-3-carboxaldehydes with substituted acetophenones in ethylene glycol and piperidine as a base gives the (E)-3-(2-(4-substitutedphenyl)-1H-indol-3-yl)-(4-substitutedphenyl) prop-2-en-1-one...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLINDAMYCIN PHOSPHATE AND CLOTRIMAZOLE IN PHARMACEUTICAL DOSAGE FORMS
A simple, efficient and reproducible Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of Clindamycin phosphate and Clotrimazole in combined soft gelatin pessaries pharm...
KARYOMORPHOLOGY AND CHROMOSOME NUMBER CONFIRMATION IN URARIA PICTA (JACQ.) DC.
Karyomorphological studies performed in Uraria picta (Jacq.) DC. (Family: Leguminosae, Subfamily: Papillionidae), an important Ayurvedic herb (Ayurvedic name: Prishni parni), revealed 7 (2n = 22; 2Lsm + 2Lscsm + 4Mm + 2M...
ANTIBIOTIC UTILIZATION STUDY IN PATIENTS WITH NOSOCOMIAL PNEUMONIA IN A PEDIATRIC HOSPITAL IN PACHUCA, HIDALGO
Objective of the study was to identify the antibiotics most frequently used for treatment of nosocomial pneumonia in the DIF Pediatric Hospital of Hidalgo and evaluate the rationality of their prescription by determining...