INDIGENOUS EFFECT OF CYNODON DACTYLON IN EXPERIMENTAL INDUCED ULCERS AND GASTRIC SECRETIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Cynodon dactylon is a perinneal grass,the plant is a rich source of metabolites such as proteins,carbohydrates mineral constituents, β-sitosterols, flavinoids, alkaloids, glycosides and triterpenoids the plant has been long used in traditional medicines to treat various alignments it also has antiviral and antimicrobial properties but none has proved its efficacy in evaluating gastro protective activity so we had made an attempt to evaluate the gastroprotective effect of extract of Cynodon dactylon in albino rats. The experiment was set up using male albino wistar rats weighing 150-180gms. These were further divided evenly into different treatment groups. The extract of Cynodon dactylon was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 100,200, 300mg/kg body weight. Histopathological assessment of rat stomach was carried out. A significant reduction (p<0.01) in ulcer index was seen in Cynodon dactylon extract treated rats of pylorus ligation, aspirin induced and ethanol induced gastric ulcer models. The gastroprotective effect was further confirmed by histopathological examination of rat stomach. Thus the present study concludes the Cynodon dactylon extract having potential gastroprotective effect in the three models tested.
Authors and Affiliations
Suresh Kondaveeti , Anand Ivvala , Kumaraswamy Dabburu , Saleem Basha, Sailaja Inampudi
Keywords
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