NASAL ROUTE: A NOVELISTIC APPROACH FOR TARGETED DRUG DELIVERY TO CNS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
Drug delivery through nasal route has attracted the interest of scientific community as it has been potentially explored as an alternative route for the administration of vaccines and biomolecules such as proteins, peptides and non-peptide drugs that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism. The nasal mucosa is one of the most permeable and highly vascularised sites for drug administration ensuring rapid absorption and onset of therapeutic action. Intranasal administration is a non-invasive route for drug delivery, which is widely used for the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the systemic circulation through the nasal mucosa, this route may also be used in a range of acute or chronic conditions requiring considerable systemic exposure. In addition it minimizes the lag time associated with oral drug delivery and offers non-invasiveness, self medication, patient comfort and patient compliance which are hurdled in intravenous drug therapy. The objective of this review is to provide an anatomical, histological and physiological overview of nose, absorption enhancers, barriers related to nasal drug delivery, physicochemical, biological and formulation related factors affecting nasal drug delivery system and its advantages. It also highlights research approaches on brain targeting through nasal cavity.
Authors and Affiliations
Rakhi Choudhary , Lakshmi Goswami
Keywords
Related Articles
- EP ID EP87410
- DOI 10.7897/2230-8407.04310
- Views 141
- Downloads 0
HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR ESTIMATION OF PANTOPRAZOLE IN INJECTION
A simple and sensitive high performance thin layer chromatography (HPTLC) method has been developed for the quantitative estimation of pantoprazole in its single component injection formulation (40 mg). Pantoprazole chro...
EVALUATION OF CENTRAL AND PERIPHERAL ANALGESIC ACTIVITY OF WHOLE PLANT GOMPHRENA GLOBOSA (L) (FAMILY: AMARANTHACEAE)
Gmophrena globosa (L) including in Amaranthaceae family is an important medicinal plant in our country, especially in hilly tribal people for their folk medicinal practices. The object of my study was to investigate the...
ATTENUATING EFFECT OF UVARIA NARUM (DUNAL) WALL. LEAVES ON THIOACETAMIDE INDUCED HEPATIC INJURY
The objective of the present study was to evaluate the hepatoprotective potential of Uvaria narum leaf extract at two different doses (200 and 400 mg / kg b.w.) against thioacetamide induced Hepatic injury. Thioacetamide...
UPDATED INSIGHT ON FOAM BINDER GRANULATION
To have updated handy reference as source of outstanding knowledge on foam binder granulation process in granulating the material(s). Granulation considered being important unit operation for producing pharmaceutical ora...
SIMULTANEOUS ESTIMATION AND VALIDATION OF VARDENAFIL AND DAPOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION BY THIN LAYER CHROMATOGRAPHIC DENSITOMETRIC METHOD
The present manuscript describes new, simple, accurate, and precise high performance thin layer chromatography method for the simultaneous determination of Vardenafil and Dapoxetine in combined tablet dosage form. Chroma...