A Pilot Study on the Relationship of the Cytoskeleton Components with Normal Cellular Functions and Injuries in Malignant and Neuro-Degenerative Multi-Factor Disorders, Using Biological Systems with Rat, Mouse and Human Origin

Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 10

Abstract

The main goal of the current study was directed to evaluation of technologies for precise identification of changes in the cellular components and compartments, composed of bio-molecules and intra-molecular structures was directed to investigation of the importance of these proteins and peptides, as well as of the intra- and extra-cellular interactions between them, for in the normal functions of the tissues and organs, but also of respective abnormalities – for the development of pathological events. The main goal of the current study was directed to evaluation of technologies for precise identification of changes in the cellular components and compartments, composed of bio-molecules and intra-molecular structures, based on differences in their electron density. Complex biological systems from human, rat and mouse, were used. In the highly differentiated mature cells in the composition of different tissues and organs, these abnormalities have been proved as main reason for abnormal functions, leading to development of diseases and disorders on organism level. These injuries in the cytoskeleton components have been suggested as reason for abnormal mitosis in the actively-dividing cells from the same individuals (as different types of undifferentiated leucocytes and their progenitors), subsequently leading to chromosomal aberrations. As one of the key molecules in the intra- and extra-cellular inter-molecular interactions by cascade regulatory pathways, in which these elements participate, has been proved the tri-peptide Glutathione, in particular, its reduced form – GSH. For a better understanding of the physiological function of cytoskeleton components, several different methods for their quantification and identification were developed and tested, including methods for 3D-imagination of cells and sub-cellular components (chromosomes), with and without additional laser irradiation, were developed and tested. Future investigations on direct and/or indirect influence of these components on the function of other biological molecules by cascade regulatory mechanisms with their participation by intra- and extra-cellular interactions are necessary.

Authors and Affiliations

Iskra Sainova

Keywords

Related Articles

Clinical profile of patients with alcoholic liver disease

Alcoholic liver disease (ALD) is a major cause of mortality and morbidity worldwide. Various studies show contradictory results about the role of amount, type and duration of alcohol exposure in determining the risk to d...

The Profile of Macrophage migration inhibitory factor (MIF) and some Immunoglobulins in patients with Autism

Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. Immunological imbalance (including aut...

Evaluation of analgesic activity of methanol extract from the Spondias pinnata

This Present study was surpassed to investigate the methanolic fruit extracts of Spondias pinnata for analgesic activities in rats using Acetic acid induced writhing test & Formalin induced licking test. S. pinnata is a...

Herbal Hair Cosmetics - An Overview

The herbal cosmetics are known as the preparation containing variety of botanical sources which influence the functions of skin and provide nutrients necessary for the healthy skin or hair. Hair cosmetics are used to inc...

Total phenols, total flavonoids content; antioxidant and antifungal activities of ethanolic and aqueous extracts of Eleutherine bulbosa (Iridaceae)

Ethanolic and aqueous extract of the bulb of Eleuterine bulbosa have been analyzed for their content in total phenols, total flavonoids; antioxidant and antifungal activities. The average value of total phenols was 27.12...

Download PDF file
  • EP ID EP202696
  • DOI -
  • Views 98
  • Downloads 0

How To Cite

Iskra Sainova (2016). A Pilot Study on the Relationship of the Cytoskeleton Components with Normal Cellular Functions and Injuries in Malignant and Neuro-Degenerative Multi-Factor Disorders, Using Biological Systems with Rat, Mouse and Human Origin. World Journal of Pharmaceutical Sciences, 4(10), 4-12. https://europub.co.uk/articles/-A-202696