A Prevalence Study of Extended Spectrum -Lactamases in Escherichia coli and Klebsiella spp. in a Tertiary Care Hospital in Rajkot City of Gujarat (India)
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 8
Abstract
Abstract:β-Lactam antibiotics are commonly used to treat bacterial infections. Increased use of antibiotics, particularly the third generation of cephalosporins, has been associated with the emergence of ESBL producing bacteria, most commonly in E. coli. And Klebsiella pneumonia. Infection due to ESBL producers range from uncomplicated urinary tract infection to life threatening sepsis. This study was undertaken to assess the prevalence of ESBL producing E.coli and Klebsiella isolates. Patients taking treatment in P.D.U. Hospital and Medical College, Rajkot- a tertiary care hospital in Gujarat, India, were included in study. During the half year period from July 2014 to December 2014, a total of 600 E. coli and Klebsiella isolates from various clinical specimens were included in the study. The isolated organisms of E. coli and Klebsiella were characterized for their production of ESBL. Out of 600 E. coli and Klebsiella isolate, E. coli were 224 (37.3% and Klebsiella spp. 376 (62.7%).The overall rate of production of ESBL (by phenotypic confirmatory test with double disc diffusion method) in total isolates of E. coli and Klebsiella spp. is 22.5% (135/600). The rate of production of ESBL in E. coli is 29.9% (67/224) and in Klebsiella spp. is 18.1% (68/376).ESBL producing E. coli and Klebsiella showed high prevalence in present study. Routine laboratory testing for ESBL is needed in order to optimize antibiotic management to reduce ESBL associated morbidity & mortality. Keywords: Extended spectrum beta-lactamase, E. coli, Klebsiella, prevalence, India.
Authors and Affiliations
Prem Prakash, Ghanshyam Kavathia
Keywords
Related Articles
- EP ID EP400050
- DOI -
- Views 68
- Downloads 0
Screening for Suspected Cases of Dengue using a Rapid Immunochromatographic Test at a Tertiary Care Centre
Dengue is a viral infection that affects millions of lives each year. A rapid screening test that would detect the NS1 antigen, IgM and IgG antibodies to recombinant antigens of all the dengue viruses helps in early dete...
Urosepsis caused by Lactococcus garvieae
Abstract: Lactococcus garvieae is a Gram-positive coccus [GPC] that has morphological and biochemical similarities to enterococci. L.garvieae strains are rare human pathogens, with only a few cases reported in the litera...
Seroprevalence of Hepatitis E Virus at Palanpur in North Gujarat
Hepatitis E virus (HEV), transmitted through the fecal–oral route is a common cause of self-limiting acute viral hepatitis in India with poor sanitation and hygiene and poses a major public health problem in I...
Evaluation of Antibacterial Activity of Achyranthesaspera Extract against Vibrio alginolyticus: An in Vitro Study
Abstract:Marine organisms are potential sources of unique natural products with pharmacological and biological activities. In mariculture, diseases of microbial origin can cause huge economic losses worldwide. The evolut...
Immunohistochemical Study of P53 and Ki 67 Expression in Surface Epithelial Tumor of the Ovary
Abstract: Surface epithelial tumors of the ovary account for approximately two-thirds of all ovarian neoplasms and their malignant forms represent about 90% of ovarian cancers. For years, efforts to identify reliable pro...