Immunohistochemical Study of P53 and Ki 67 Expression in Surface Epithelial Tumor of the Ovary
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2017, Vol 2, Issue 3
Abstract
Abstract: Surface epithelial tumors of the ovary account for approximately two-thirds of all ovarian neoplasms and their malignant forms represent about 90% of ovarian cancers. For years, efforts to identify reliable prognostic factors have focused on molecular markers; large number of them has been investigated to date, usually by immunohistochemistry. Mutation of the p53 gene has been reported in a variety of human malignant tumors and it has been claimed to be a marker of poor prognosis. Aim of the study is to assess the immunoexpression of p53 and Ki 67 in surface epithelial tumors of the ovary and to evaluate their correlation with the clinicopathological parameters. There were 60 cases of surface epithelial tumors encountered over the period of 7 years from 2007 to 2014 in addition to10 samples of non-neoplastic ovarian tissues were included as a control. The samples were collected from Hawler Maternity Teaching Hospital. Formalin fixed, paraffin-embedded specimens were studied and sections were prepared for immunohistochemical staining for both p53 and Ki 67 markers. Ethical consent has been obtained from Hawler Medical University. Data were analyzed using the Statistical Package for Social Sciences (SPSS, version 19). High immunoexpression of p53 and Ki 67 were seen in patients with ovarian tumor aged more than 40 years. Statically highly significant correlation was found in the immunoexpression of both p53 and Ki 67 marker between benign, borderline and malignant surface epithelial tumors ( P value < 0.05); while no significant correlation was found between their expression in relation to tumor grade and stage in epithelial ovarian cancer. Maximal immunoexpression of p53 and Ki-67 immunohistochemical markers was seen in epithelial ovarian cancer, this emphasizes their important carcinogenic role in surface epithelial tumor of the ovary. Their over expressions are not correlated with tumor grade and stage. Keywords: P53, Ki 67 immunohistochemical markers and ovarian tumors.
Authors and Affiliations
Yusra Abdulkhaliq Qasim, Shatha Zaker Saeed, Ilham Majeed Rashid
Keywords
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