A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 5
Abstract
About 60-70% of the drugs synthesized are poorly soluble and comes under BCS Class-II&IV. Now it is a challenging situation during the development of different dosage forms for pharmaceutical industries because solubility of the drug is the rate limiting step. Based on the solubility, the dissolution, bioavailability & therapeutic effect is dependent. To overcome this consequence a novel technique -Liquisolid compact is used by dissolving the poorly soluble drug in a non-volatile solvent that improves wettability & decreases the surface tension and ensures drug molecular dispersion in the formulation to increase the solubility of the drug. This admixture of drug loaded solution is blended with carrier adsorption & coating material (adsorption) that has free flowing and compressible powder properties.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP494860
- DOI 10.22270/jddt.v8i5.1919
- Views 73
- Downloads 0
PHARMACOLOGICAL INVESTIGATION OF LEAVES OF POLYPODIUM DECUMANUM FOR ANTIDIABETIC ACTIVITY
This research was performed to characterize the hypoglycemic effect of ethanolic extract of Polypodium decumanum leaves in alloxanized diabetic rats. The ethanolic extract of Polypodium decumanum leaves was administered...
FORMULATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET CONTAINING CASSIA TORA MUCILAGE
All the present investigation an attempt has been made to study the formulation and evaluation of matrix tablet of Metformin HCL using natural mucilage of Cassia tora as a release retardant. The matrix tablet was formula...
INCREDIBLE TASTE MASKING OF CLARITHROMYCIN
Clarithromycin has poor acceptance by pediatric and geriatric patients due to bitter taste. Usually, in dry syrup formulations, high concentration of sugar is used for taste masking. But high consumption of sugar is rela...
In-vitro cytotoxicity of java tea mediated selenium nanoballs against L6 cell lines
The emergence of Nanotechnology has provided a catholic research in recent years by intersecting with assorted branches of science and forming collision on all forms of life. At present there has been a prodigious excite...
FLOW AND COMPACTION PROPERTIES OF THE MODIFIED BIOMATERIAL POWDER DERIVED FROM THE TYMPANOTONUS FUSCATA SHELL
A modified biomaterial powder derived from Tympanotonus fuscata shell was evaluated for its flow and compaction properties towards possible application in the directly compressible technology of tablet production. The pu...