A Prospective Comparative Study of Efficacy of Zoledronic Acid Vs Teriparatide On Bone Mineral Density Via Dexa Scan in Post Menopausal Osteoporosis
Journal Title: UNKNOWN - Year 2017, Vol 6, Issue 3
Abstract
Aim: To study and compare the effect of zoledronic acid and teriparatide on bone mineral density in postmenopausal women with osteoporosis. Material and methods: 100 postmenopausal patients having BMD score <-1 were selected from the outpatient department of Gynecology, S.N. Medical College, Agra. The study was undertaken in collaboration with Orthopedician. Randomly divided into two groups.Group-A: 50 patients given 5 mg Iv zoledronic acid infusion, 2 such doses were given at 6 months interval.Group-B: 50 patients given 20 µg/day teriparatide by subcutaneous injection for 3 months.Follow up at 12 months and BMD score are compared. Results: There was significant increase in BMD in both the groups over a period of one year but increase was more significant in teriparatide group (8 to 10%) as compared to 4-6% increase in zoledronic acid group. Clinical symptoms improved in both groups with fewer side effects in teriparatide group. Conclusion: Both teriparatide and zoledronic acid are good options for management of postmenopausal osteoporosis with teriparatide having better clinical efficacy and less side effects though it is expensive and requires daily administration.
Authors and Affiliations
Meenal Jain, Amit Agarwal, Ruchika Garg
Keywords
Related Articles
- EP ID EP366102
- DOI -
- Views 114
- Downloads 0
Determinants of contraceptive usage among the slum dwelling migrant women in coastal Karnataka, India – A mixed methods study
Background: The coastal districts of Karnataka, India have been attracting migrant workers for decades and majority of these labor migrants reside in slums. Limited data is available on the contraceptive behaviours of sl...
Pre-stroke statin use was associated with lower risk of in-hospital death in non-thrombolysed patients
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischemi...
Prospective Study of Sickle Beta Thalassemia in A Tertiary Care Hospital
Background: Sickle cell beta thalassemia (Hb S/β Thal) is an inherited form of sickle cell disease that affects red blood cells both in the production of abnormal hemoglobin as well as the decreased synthesis of beta glo...
Does the maternal position at the time of administration of subarachnoid block with plain Ropivacaine affect the hemodynamics? A comparative evaluation of the sitting versus lateral position
Background: Subarachnoid block is the preferred anesthesia in the parturient undergoing elective caesarean section. The ideal position for the induction of subarachnoid block in a parturient is not standardized and its e...
Analysis of Urinary Organic Acid Profile in Clinically Suspected Patients
Background: Qualitative urinary organic acid profile analysis with gas chromatography/mass spectrometry is used in the diagnosing and monitoring of organic acid disorders. The aim of this study is to verify organic acid...