Analysis of Urinary Organic Acid Profile in Clinically Suspected Patients
Journal Title: UNKNOWN - Year 2016, Vol 5, Issue 4
Abstract
Background: Qualitative urinary organic acid profile analysis with gas chromatography/mass spectrometry is used in the diagnosing and monitoring of organic acid disorders. The aim of this study is to verify organic acid testing using diagnostic sensitivity and specificity in routine clinical laboratory. Methods: Cutoff limits of urinary organic acids were determined as the 95th percentile of healthy volunteers’ results. Data of patients submitted to our laboratory were evaluated. Out of 900 clinically suspected patients 25 were diagnosed with 9 different organic acid disorders. Results: Results of diagnostic compounds of patients with organic acid disorders were higher than cutoff limits. This reflects sensitivity. Median values of organic acids of the patient group with no specific organic acidemia were all below the cutoff limit which reflects the specificity of the test. Conclusion: We suggest that routine laboratories should determine their own cutoff limits and evaluate the overall effectiveness for urinary organic acid profile analysis.
Authors and Affiliations
Sezer Uysal, Canan Çoker, Yeşim Öztürk, Nur Arslan
Keywords
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