A Prospective Evaluation of Predictive Risk Factors, Severity of Liver Injury and Course of Anti –Tubercular Treatment Induced Hepatotoxicity
Journal Title: National Journal of Medical Research - Year 2018, Vol 8, Issue 1
Abstract
"Background: Hepatotoxicity is an established complication of Anti-tubercular treatment. However, there is limited information on the incidence, possible predictive risk factors and course of anti- tubercular treat-ment induced hepatotoxicity. Objective: The study was planned to evaluate incidence, possible predictive risk factors and course of anti-tubercular treatment induced hepatotoxicity (ATTIH ) . Methodology: The present prospective study was conducted with Newly diagnosed pulmonary and extra-pulmonary tuberculosis patients admitted from may 2014 to may 2016.A sample size of 150 patients were put on ATT ranging from 6 months to 12 months depending on type of Tuberculosis. Their pretreatment clinical, biochemical and radiological parameters were recorded. These parameters were compared between cases and controls by appropriate statistical methods. Patients with abnormal base line LFT’S, Treatment defaulters, failure, MDR cases and patients with NASH, cirrhosis ,acute viral hepatitis &/or renal or cardiac disease were excluded from this study. Results: Out of 150 patients 22 patients (14.7%) developed ATTIH. Among 22 patients 15 (68.2%) were females and 7 (31.8%) were males. Higher incidence of ATTIH was seen in patients with low BMI of 18.99kg/m2(45.16%), pretreatment low serum albumin <2.5gm( 65.21%), Corrected calcium < 7.9gm/dl( 58.8%), Serum cholesterol < 200mg/dl (59.1%), Extra pulmonary TB(69.3%), concomitant paracetamol in-take(77.7%). Age and consanguinity were statistically insignificant. In this study 18 patients (81.81%) devel-oped ATTIH within 2 weeks of starting ATT with average of 9 days and severity of liver injury ranged from mild with ALT ( 51-250IU/L) in 12(54.5%), intermediate (251-500IU/L) in 7 ( 31.8%) and severe (ALT >500IU/L) in 3(13.6%). Normalization of LFTs after ATTIH was seen within first 2 weeks in 11(50%) patients with average of 11 days. ATTIH was associated with prolongation of expected treatment duration in 16 (72.7%) patients. Recurrence of ATTIH was not seen in any patient on reintroduction of treatment. Among 22 patients, 19(86.36%) were cured, 2(9.1%) expired and 1 patient lost follow up. Conclusion: Early identification of predictive risk factors, modification of treatment with close monitoring and hospitalization are required for reducing morbidity, mortality and treatment completion in ATTIH. "
Authors and Affiliations
Waseem Javid, Majid Abbas Khawaja, Ghulam Nabi Dhobi
Keywords
Related Articles
- EP ID EP602526
- DOI -
- Views 112
- Downloads 0
Regional Variation of Morphometric Measurements of Proximal End of Femur in Coastal Andhra Pradesh and its Clinical Implication to Improve Surgical Outcome
Introduction: The neck of femur is an important modification in human being. The neck-shaft angle and different parameters of neck are clinically important to diagnose pathological conditions of the hip joint and also he...
Socio Demographic and Clinical Factors associated with TB Meningitis among HIV Positive Patients
"Introduction: Infection with HIV is associated with increased risk of activation of latent infection of Tuberculosis, as well as increased risk of rapid progression of primary infection, without an intervening period of...
An Observational Study on Implication of Educational Level on Control and Long-Term Complications of Diabetes Mellitus In a Tertiary Care Hospital of Eastern India
Introduction: The strongest environmental risk factor for diabetes, obesity, is related to socio-economic status. Due to lack of education in India, several myths and social stigma add to the problems of managing Diabete...
A Comparative Study Efficacy of Ondansetron versus Granisetron to Prevent Perioperative Nausea and Vomiting among Patients Undergoing Gynaecological Surgery Under Spinal Anaesthesia in a Tertiary Care Hospital of Western India
"Background: In India Post-Operative Nausea and vomiting (PONV) remains a persistent and distressing problem in spite of many advances on perioperative care and anti-emetic medicines. A randomized double blind study was...
Patient Activation Measures in Type2 DM in Tertiary Care Hospital – Does it Differ between Male and Female
"Introduction: Type 2 diabetes is characterised by relative insulin deficiency caused by pancreatic β-cell dys-function and insulin resistance in target organs. The Patient Activation Measure is a valid, highly reliable,...