A prospective, randomized, controlled trial of autologous platelet - rich plasma for the treatment of diabetic foot ulcers
Journal Title: Medpulse International Journal of Surgery - Year 2017, Vol 1, Issue 3
Abstract
Objective: To evaluate the safety and efficacy of autologous platelet-rich plasma for the treatment of nonhealing diabetic foot ulcers. Methods: Type of study – Prospective Randomized Controlled Blinded clinical study. Sample size – 50. The patients admitted with diabetic foot ulcer in surgery wards in Vinayaka Missions Medical College and Hospital, Karaikal. Inclusion criteria: Persons with type 2 diabetes. Age more than 18 years. Ulcer of at least 4 weeks’ duration. Hba1c < 8. Foot ulcer located on the plantar, medial, or lateral aspect of the foot. Wound measurement between 3 cm and 5 cm. Post debridement, the ulcer should be comprised of healthy vascularized tissue and free of necrotic debris, foreign bodies, sinus tracts, tunneling, and undermining and at least 4 cm from any additional wound. Limb with adequate perfusion. Exclusion criteria: Ulcer due to non-diabetic etiology. Evidence of gangrene in ulcer or on any part of the foot. Patients undergoing renal dialysis, known immune insufficiency, known abnormal platelet activation disorders, liver disease, active cancer (except remote basal cell of the skin), malnutrition, hematologic, collagen vascular disease, rheumatic disease, or bleeding disorders. Women of childbearing age excluding pregnant or lactating. Conclusion: It was observed that postmenopausal women with thyroid dysfunction, especially subclinical hypothyroidism, had lipid abnormalities. Lipid abnormalities seen in subclinical hypothyroidism patients are mainly in the form of significant elevation of total cholesterol and HDL. According to this study, thyroid dysfunction is directly related to total cholesterol and HDL changes (p< 0.01).Changes have also been noted with thyroid dysfunction and Non HDL Cholesterol mainly LDL and VLDL but, they were not statistically significant. Therefore, in post menopausal women with thyroid dysfunction evaluation of lipid profile should me made mandatory to avoid the risk of Coronary artery disease, Cerebrovascular accident.
Authors and Affiliations
Bella Lissy Ben, B Sankararaman, G Ambujam, Shigil Mathew Varghese
Keywords
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- EP ID EP481944
- DOI 10.26611/106132
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