A prospective randomized double blind study comparing isobaric ropivacaine 0.5% with dexmedetomidine and 0.5% ropivacaine alone in spinal anaesthesia in lower limb and perineal surgeries
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 4
Abstract
Introduction: The versatility of spinal anaesthesia is afforded by a wide range of local anaesthetics and additives that allow control over the level, the time of onset and the duration of spinal anaesthesia. The present study was conducted to compare the effects of isobaric ropivacaine 0.5% with and without dexmedetomidine 5 mcg in spinal anaesthesia in lower limb and perineal surgeries in terms of the onset of sensory and motor block, duration of sensory and motor block, and duration of analgesia. Material and Methods: In this prospective randomized double blind study, 60 patients of physical status ASA I & II scheduled for lower limb and perineal surgeries under the subarachnoid block were randomized to receive either intrathecal 3 ml of 0.5% isobaric ropivacaine with 0.05 ml of 5 mcg preservative dexmedetomidine (Group RD, n=30) or 3 ml of 0.5% isobaric ropivacaine with 1 ml of normal saline (Group R, n=30). Onset of sensory block, maximum level of sensory block, time taken to achieve maximum sensory level and duration of sensory block was noted. The degree of motor block was assessed every 5 min for first 30 min and then every 15 min till completion of surgery. Results: The mean time for onset of sensory block was 8.23±2.91 min in Group RD and 8.76 ± 2.97 min in Group R. The mean time for onset of motor block in group RD was 11.8±2.52min and 12.46 ± 2.51 min in group R. The mean duration of sensory block was prolonged (191.03±32.97min) in group RD than group R (169.13±30.98 min). The mean duration of motor block was also prolonged in group RD than group R (4.41±0.49 hrs vs 3.6 ±0.55 hrs The mean duration of analgesia was 7.52 ± 2.10 hrs in group RD and4.25 ± 1.80 hrs in group R. Hypotension was observed in 4 (13.33%) patients in group RD and in (6.66%) patients of group R. Bradycardia was observed in 2 (6.66%) patients from both the groups. Conclusion: We conclude that Dexmedetomidine as an adjunct to 0.5% Ropivacaine is superior to 0.5% Ropivacaine alone in spinal anaesthesia. It augments the onset and duration of sensory and motor block, as well as total duration of analgesia thus, reducing the requirement of analgesics in postoperative period.
Authors and Affiliations
Dr. Anand Prasoon, Dr. Shraddha Naik, Dr. PB Jamale, Dr. VK Dhulkhed, Dr. Siddharth Sharma
Keywords
Related Articles
- EP ID EP585497
- DOI -
- Views 138
- Downloads 0
Evaluation of biliary leakage in patient’s undergone cholecystectomy
Cystic duct and accessory bile duct leaks are generally treated easily without a problem. Stricture development after endoscopic treatment of main bile duct leaks, even in patients without stricture at the beginning, is...
Incidence of multi drug resistant Acinetobacter species in intensive care units at a tertiary care hospital
Acinetobacter species are nonfermenting Gram negative coccobacilli once considered to be opportunistic pathogens has recently emerged as an important nosocomial pathogens. The purpose of this study is to know the inciden...
Glycated hemoglobin for the diagnosis of diabetes and prediabetes
Introduction:Measurement of glycated hemoglobin (HbA1c) has been recommended for the diagnosis of diabetes and prediabetes. However, epidemiological studies have shown significant discordance between HbA1c and glucose-ba...
Assessment of origin of sinoatrial nodal artery in human cadaveric hearts
The sinoatrial nodal artery usually arises from the right coronary artery or circumflex branch of left coronary artery or from both right and left coronary arteries. Hence present study was planned to assess the accurate...
Magnesium supplementation improve outcome after cardiac surgery
Hypomagnesaemia is common after cardiac surgery when done under cardiopulmonary bypass and it has association with increased morbidity and mortality. The purpose of this study was to determine whether magnesium supplemen...