A prospective study for the association between kidney disease and pre-diabetes
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 12
Abstract
Background: Globally, diabetes is the leading cause of kidney disease and kidney failure. Prediabetes is approximately twice as common as diabetes, affecting 20-35% of adults. The fasting glucose and glycated haemoglobin (HbA1c) levels consistent with prediabetes are independent risk factors for hyper filtration in the kidneys and the presence of albumin in the urine -both indicators of kidney damage. Aims and Objectives: To study the association between pre-diabetes and kidney diseases. Materials and Methods: This is a prospective study which was conducted on 150 subjects with 50 normoglycemic controls and 100 pre-diabetes patients having fasting plasma glucose (FPG) more than 100 mg/dl and less than 126 mg/dl or Postprandial Blood Sugar (PPBS) more than 140mg/dl or less than 199mg/dl and /or HbA1c 5.6 to 6.4%. Physio-chemical parameters were recorded and assessed to understand the correlation between pre-diabetic conditions and kidney disease. Results: Kidney disease prevalence is high among people with prediabetes. Majority of the cases had fasting blood between 100- 109 mg/dl, all controls had FBS range less than 100 mg/dl. Mean FBS in cases was 111.28±7.06 mg/dl and mean FBS in controls was (77.62±10.2 mg/dl. Post prandial blood sugar in pre diabetic cases ranged from 160- 179, all controls had PPBS< 140 mg/dl, mean PPBS in cases was 171.4±13.63 mg/dl and mean PPBS in controls was 116.52±12.86 mg/dl. Hb1c in pre-diabetic cases ranged from 5.7 – 6.0%, all controls had HbA1c <5.7%, mean HbA1c in cases was 6.03±0.19 and mean HbA1c in controls was 4.5±0.61%. 18% cases and none of the controls showed evidence of kidney disease. This difference of evidence of kidney disease between cases and controls was statistically significant. Conclusion: Kidney disease prevalence was high among the prediabetes patients. Thus prediabetes can be target for early intervention for prevention of chronic kidney diseases by lifestyle changes.
Authors and Affiliations
Dr. Shilpi Sikarwar, Dr. Ajay Pal Singh
Keywords
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