A prospective study of correlation between hormonal profile and acne vulgaris in adult patients
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 2
Abstract
Introduction Although various studies has been conducted regarding pathogenesis of acne vulgaris and proved it to be multi factorial but there is strong association between acne vulgaris and hormone profile of patients Present study has been designed to document and access the correlation between hormone profile and acne vulgeris with a primary aim to know the hormonal profile of acne vulgaris patient and correlate the hormone level with acne vulgaris patientsMaterials and Methods This study is prospective randomized case control study conducted in the dept of dermatology venereology and leprology Konaseema institute of medical science Amalapuram Andhra Pradesh from August 2015 to April 2018 In present study 80 clinically diagnosed acne vulgeris patients were randomly selected for this study based on inclusion and exclusion criteria Another 80 age and sex matched healthy volunteers were taken as control group who are free from acneResult Mean serum concentration of testosterone was 83542831ngdl in cases but in control group mean serum concentration was 48893879 ngdl with P value 000001 Mean of serum DHEAS concentration was 265795348 mcgdl in patients but in healthy volunteers it was 211483611 mcgdl with P value 000012Serum insulin level in acne patients were meanSD 7163 1843 mIUL but in control group it was 548 124 mIUL with P value 00019 Mean concentration of serum glucocorticoid was 1463324mcgdl in cases but in control it was 1342494 mcgdl having P value 089 Serum IGF1 mean value was 272626232 ngml in cases and 246767032ngml in control with P value 0074 Serum ACTH concentration was 3966 424pgml in cases mean SD but in control 3360 992pgml with P value 00035Discussion and Conclusion Serum concentration of testosterone DHEAS ACTH and IGF1 level was higher in acne vulgeris cases then control which indicate a correlation between these hormone and acne vulgeris Increase in serum level of insulin and HOMAIR value suggests an insulin resistance state in acne vulgeris We have also found a correlation between PCOS and acne vulgerisKeywords Hormonal profile Acne vulgaris Adult patients
Authors and Affiliations
MSN Murthy, Kadi Ramesh
Keywords
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- EP ID EP488882
- DOI 10.18231/2581-4729.2018.0034
- Views 81
- Downloads 0
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