A Prospective Study of Safety and Efficacy of Thalidomide in Dermatology in a Tertiary care centre - Tamilnadu
Journal Title: Stanley Medical Journal - Year 2017, Vol 4, Issue 1
Abstract
Context: Thalidomide can be safely and effectively used in the treatment of Erythema Nodosum Leprosum(ENL), Pyoderma gangrenosum(PG),Discoid Lupus Erythematosus(DLE).Aims: The use of thalidomide in relation to dermatology is well- known. Enough data is available in the literature about various aspects of thalidomide. Our study aims to assess the safety and efficacy of Thalidomide in patients with ENL, PG, DLE and psoriasis who were refractory to conventional treatment.Settings and Design:The study was done in the Dermatology Department, Govt. Stanley medical college hospital using a prospective study design.Methods and Material: The study was an open label, prospective interventional study. The Study population included 20 patients each of ENL, Pyoderma gangrenosum, psoriasis and 10 DLE patients. Inclusion and Exclusion criteria were fulfilled.Statistical analysis used: nil Results: The response to thalidomide was excellent in 3 of the 4 conditions we studied. Our study implies that Thalidomide can be safely and effectively used in the treatment of ENL, Pyoderma gangrenosum, DLE, though the clinical response to treatment in Psoriasis is not much satisfactory.Conclusions:Thalidomide with its excellent tolerability can be used for many dermatological conditions as an alternative when other modalities are contraindicated or ineffective. Key Messages: Thalidomide is safe and effective
Authors and Affiliations
Senthil Kumar V, Afthab Jameela Wahab . , Anandan V, Sivaranjani J
Keywords
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