A Prospective Study of Tread Mill Test in Postmenopausal Women

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A Prospective Study of Tread Mill Test in Postmenopausal Women

Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 4

Abstract

Introduction: Cardiovascular disease (CVD) accounts for 45% mortality in women. In post menopausal women risk factors like hypertension, dyslipidemia, obesity and diabetes are increasing. Cardiovascular risk assessment should be done at time of menopause and at regular intervals to detect cardiovascular disorders at the earliest. Current research aimed to study symptomatology and biochemical parameter and its relationship with ECG and TMT in postmenopausal women. Material and Methods: Ninety postmenopausal women (40- 50 years) were studied between January 2016 to September 2017 at Department of Medicine, J.A. Group of Hospitals, G.R. Medical College, and Gwalior. Patients were randomly divided as Cases (n=60; patients having at least one risk factor for CAD) and Control (n=30; patients with no risk factor for CAD). Postmenopausal symptoms, age, blood sugar, HbA1C and ECG were done in all patients. Treadmill test, ECG, TSH and urine for microalbuminuria were performed in all subjects. Data were analyzed using IBM SPSS ver. 20 software. P value of <0.05 is considered as significant. Results: Mean age at menopause was 46.7 years, mean duration since menopause was 4.6 years, most of the subjects were illiterate (84%), had sedentary life style (88%) and were vegetarian (76%).Most common post menopausal symptoms were weakness/lethargy(60%), adverse mood (21.66%) and sleep disturbance (16.66%). Among cases and control, 9 and 1 patients was TMT positive (p<0.001). TMT was positive in one patient with night sweat (n=3), 5 patients with hot flashes (n=14), 2 patients with weight gain (n=4) and 1 patients with dyspareunia (n=2). Out of 9 TMT positive cases most of them were having BMI between 18.5-24.9 kg/m2 (n=7), HbA1c <6.5% (n=7), total Cholesterol >200 mg/dl (n=5), Triglyceride >150 mg/dl (n=5), HDL <40 (n=7), LDL >130 (n=5), VLDL >30 (n=6) and TSH between 4.25 to 10 (n=3). TMT was also positive in one patient with LAE, 2 patients of low voltage complex, 5 patients with non specific ST-T changes and one patient with sinus bradycardia in ECG findings. Among risk factors TMT was positive in 6 patients with dyslipidemia, 2 patients with diabetes, 3 patients with hypothyroidism and 1 patient who was overweight. Conclusion: TMT can help in early diagnosis and warrants further action and it is a good non-invasive screening tool for CAD in postmenopausal women.TMT is an important tool specially in postmenopausal women who are at 40-45 years of age to screen CAD.

Authors and Affiliations

Sutakshee Sonwani, Ram Awatar Rawat, Puneet Rastogi, O P Jatav

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