A prospective study on the efficacy of two drug combination chemotherapy in patients with malignant gonadal germ cell TUMORS
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 1
Abstract
Malignant gonadal germ cell tumors are the rare malignant tumors which occurs in young individuals at the peak of their reproductive life between 18- 45yrs. Germ cell tumors are sensitive to chemotherapy as well as radiotherapy . Three and four drugs regimen increases the survival of 80-90% with increased drug induced toxicity. This study is to find out the efficacy of two drug regimen with cisplatin and etoposide response in malignant gonadal germ cell tumor . The study was carried out in a tertiary care hospital for a period of 21 months. Twenty six patients were selected and six patients were excluded. Prior to treatment all patients were evaluated with basic investigations. αFP and β HCG levels were estimated before and after chemotherapy. Cisplatin 20mg /m² and Etoposide 75mg/m² was given daily for five consecutive days at an interval of 21 days in four cycles. Patients were observed for adverse effects during the course of therapy. Response was evaluated by evidence of regression of the documented tumors and measuring serum tumor markers level . In this study 85% of patients were complete responders and side effects also less during treatment and the follow up period. 5% were partial responders and 10% were non responders. Partial and non responders were recommended for an alternative therapy.
Authors and Affiliations
Sudha R
Keywords
Related Articles
- EP ID EP535906
- DOI -
- Views 108
- Downloads 0
Evaluation of therapeutic outcomes and non pharmacological therapy in patients with chronic tension-type headache presenting to a secondary care hospital
Chronic tension-type headache (CTTH) is defined as severe and persisting pain in the head with the pain being above the eyes behind the head and undoubtedly one of the most frustrating symptoms that physicians encounter...
GC-MS evaluation of Fatty acid constituents from various tissues of Macrobrachium scabriculum
Macrobrachium scabriculum is a tastiest freshwater prawn belongs to the family Palaemonidae available throughout the year in the river Cauvery. The present study deals with the extraction and GC-MS analysis of fatty aci...
A Comparison of Intranasal Dexmedetomidine and Midazolam for Premedication in children - A prospective randomised double blind controlled trial
In children, preanesthetic medications are administered to alleviate the stress and fear of surgery, to ease child-parent separation and to promote a smoother induction of anesthesia. Midazolam is a commonly used drug fo...
Demographic profile in urinary tract infection
Introduction Urinary tract infection (UTI) is the most frequent community-acquired infection worldwide between 1 year and 50 years of age. UTI and recurrent UTI are predominantly disease of females. In uncomplicated UTI...
Study of efficacy and safety of second line art regimen in HIV/AIDS patients in a tertiary care centre
Background The advent of HAART has decreased the progression to AIDS and AIDS related mortality and prolonged the survival .On the other hand, advances in the antiretroviral therapy have increased life span of HIV posit...