A Comparison of Intranasal Dexmedetomidine and Midazolam for Premedication in children - A prospective randomised double blind controlled trial
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
In children, preanesthetic medications are administered to alleviate the stress and fear of surgery, to ease child-parent separation and to promote a smoother induction of anesthesia. Midazolam is a commonly used drug for this purpose. Clonidine, an 2 agonist, has been suggested as an alternative. Dexmedetomidine is a more 2 selectivedrug than clonidine and has favourable pharmacokinetic properties. The sedation produced by dexmedetomidine differs from other sedatives in that the patients are easily aroused and are cooperative. Intranasal administration of preanaesthetic medications is relatively easy and gives a high bioavailability of the drugs than oral route. We compared intranasal dexmedetomidine with intranasal midazolam for premedication in children. We conclude that children premedicated with 1 µg/kg of intranasal dexmedetomidine attained more significant and satisfactory levels of sedation at parental separation and at induction of anesthesia than those patients who received 0.2mg/kg of intranasal midazolam. The change in behaviour produced is favourable and is similar with both drugs. The changes in heart rate and blood pressure observed with intranasal dexmeditomidine are clinically insignificant and are manageable.
Authors and Affiliations
Prabhu Thilaak
Keywords
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