Abstract

Aspirin loaded microsponge can be used to deliver particles to the intestinal region for reducing the side effects and give sustained release effect. Quasi emulsion solvent diffusion method was used to prepare Aspirin loaded microsponge by using Eudragit RS100 as polymer, polyvinyl alcohol as emulsifier, Triethyl citrate as plasticizer, Dichloromethane and methanol as solvent. Optimization of formulation was done by Central Composite design with 15 runs. 3-D surface response plots and contour plots were drawn and optimized formulation was selected by check point batch. Evaluation of formulation were done by Particle size, loading efficiency, production yield, drug content, %CDR at 1 hr, t50%, t90% along with scanning electron microscopy, Residual solvent study, DSC, FTIR also characterized. Spray coating was done by using coater with nozzle spray. Mechanically strong tablets were obtained owing to the plastic deformation of sponge-like structure of microsponges confirmed by resillency test. All the factors studied had an influence on the physical characteristics of the microsponges. In-vitro dissolution studies were done on all formulations and the results were kinetically evaluated and the release rate of aspirin was found to be modified. This study presents a new approach based on microsponge drug delivery system, drug release in sustained manner with reducing the side effect

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