A review on carbapenem resistance and the role of pharmacist in antibiotic stewardship programmes in India
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 1
Abstract
Carbapenems are a group of β-lactam antimicrobial agents with an exceptionally broad spectrum of activity. They are used as a last resort against many multi drug resistant, gram negative bacteria, and in cases of infections due to extended spectrum beta lactamase (ESBL) and Amp C enzyme producing Enterobacteriaceae. CRE, which stands for carbapenem-resistant Enterobacteriaceae, are a family of germs that are difficult to treat because they have high levels of resistance to antibiotics. However, widespread and irrational use of carbapenems has led to emergence of resistance to this group of drugs also, and there are at present very few available antibiotics, which are active against carbapenem-resistant (CR) organisms. Infections with CR organisms are associated with high morbidity and mortality with the attributable mortality rate as high as 40-50%. Carbapenem resistance is a global concern and the presence of CR genes in Indian subcontinent and its potential of international spread have been reported previously. Pharmacists have a responsibility to assist in the war on antibiotic resistance. They have the knowledge and resources at their fingertips to raise awareness and to act. There are multiple opportunities for pharmacists to assist in this campaign. The recognition of pharmacists as key members of antibiotic stewardship teams in health systems is a milestone in infectious-diseases pharmacy practice
Authors and Affiliations
Hrishi V
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