Adverse neurological events due to antiretroviral therapy in Mali
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 4
Abstract
Introduction Adverse neurological events during antiretroviral treatment (ART) are frequent and various1-3. Their diagnosis is difficult in developing countries where human resources and infrastructures are most of the time lacking. Aim To identify the frequency of neurological side effects in patients under ART in Mali Methods We performed a prospective cohort study on patients developing neurological symptoms in a period of 12 months at the Department of Infectious Diseases of the Teaching Hospital “Point G” of Bamako, Mali. Neurological diagnostic was established with the guidance of a neurologist. WHO’s sides effects table has been used to characterize and classify the side effects4. Analysis of data was performed with SPSS Software, version 12.0. Results A total of 420 HIV seropositive patients under ART have been followed. Of those, 37 cases were found with adverse neurological events (8.08%). The sex ratio M/F was 1.06 and. the mean age was 41.2 years. Of the side effects, polyneuritis alone represented 83.8% of the cases, and polyneuritis associated to vertigo, headache and depression represented the remaining 16.2 %. We didn’t notice any these neurological symptoms at the initiation of the ART. The majority of the patients was infected by HIV-1 (91.9 %). Most of the patients, 89.2% were treated with a fixed dose combination of Triomune® (D4T+3TC +Nevirapine). Five cases were at 3rd stage of WHO classification (13.5%), which justified stopping the treatment with d4T. Conclusions The use of Triomune® led to neurological adverse events in Mali. Any further new antiretroviral regimens must include a pharmacovigilance to detect eventual neurological side effects.
Authors and Affiliations
Oumar AA
Keywords
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