The use of electric current – Iontophoresis for transcutaneous drug delivery – Novel drug delivery system (NDDS)
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 3
Abstract
The method by which a drug is delivered can have a significant effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is delivered, and concentrations above or below this range can be toxic or produce no therapeutic benefit at all. On the other hand, the very slow progress in the efficacy of the treatment of severe diseases, has suggested a growing need for a multidisciplinary approach to the delivery of therapeutics to the targets in tissues with new ideas on controlling the pharmacokinetics, pharmacodynamics, non- specific toxicity, immunogenicity, bio recognition, and efficacy of drugs. These new strategies often called drug delivery system (DDS) are based on interdisciplinary approaches that combine polymer science, pharmaceutics, bio conjugate chemistry, and molecular biology and have generated much attention during the last decades. Drugs administered through these systems escape first-pas metabolism and maintain a steady state scenario similar to a continuous intravenous infusion for up to several days. However, the excellent impervious nature of the skin offers the greatest challenge for successful delivery of drug molecules by utilizing the concepts of iontophoresis. The rationale behind using these techniques is to reversibly alter the barrier properties of skin, which could possibly improve the penetration of drugs to increase the systemic delivery with controlled input kinetics and minimum inter- subject variability.
Authors and Affiliations
Mohammad Younis Bhat
Keywords
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