A Randomized Controlled Trial Comparing the Efficacy of Atorvastatin and Metformin in the Patients with Polycystic Ovary Syndrome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
INTRODUCTION: Polycystic ovary syndrome(PCOS) may be associated with overweight and obesity,hyperandrogenism, insulin resistance and impaired glucose tolerance, anovulation and infertility and abnormal lipid profile. Aim of our study is to compare the efficacy of metformin and atorvastatin in treatment of PCOS. METHODS: A total of 108 patients suffering from polycystic ovary syndrome were recruited in this study according to Modified Rotterdam criteria. They were divided into equal three groups each comprising of 36 patients. They were given single blind (patient) treatment either with metformin (500mg twice daily) or atorvastatin (20mg once daily) or with both (metformin 500mg twice daily and atorvastatin 20mg once daily). The patients were followed up at the end of third month with appropriate investigations. RESULTS: Reduction of BMI after three months treatment was statistically significant in each of three groups (metformin, atorvastatin and combined group). Total testosterone level (ng/dl) was decreased significantly only in metformin group (p value 0.001) but not in atorvastatin or in combined group. Insulin resistance (HOMA-IR) was decreased significantly in each of the three groups after treatment and it was comparable at baseline and after three months of treatment across the groups (p value 0.2355 and 0.8176). There were minor difference in improvement of lipid profile, improvement of hirsutism (FG score) and acne(acne score) among the groups. Conclusion: Treatment with atorvastatin and combination of drugs (metformin and atorvastatin) are as effective as metformin in reducing BMI, total testosterone level, fasting insulin level, FBS, PPBS, insulin resistance.
Authors and Affiliations
Dr Chanchal Bhowmick, Dr Pallab Kumar Mistri, Dr Payel Roy, Prof. Bhaskarananda Seal
Keywords
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- EP ID EP428648
- DOI 10.9790/0853-1712113842.
- Views 63
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