Study of Inverse Association BetweenIntercellular Adhesion and Malignant Cell Propagation in Gall bladder CarcinomaImmunohistochemicalStudy of E-Cadherin and Autocrine Motility Factor Receptor
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Though incidence of Gall bladder carcinoma is most common biliary tract cancers, nonspecific presenting symptom, late detection of the disease add to the dismal prognosis We tried to find association between intercellular adhesion and propagation of cancer cell in Adenocarcinoma of Gall bladder. E-cadherin (ECAD) is the strongest intercellular adhesion molecule of epithelial cells and Autocrine Motility Factor (AMFR) is known propagator of cancer cell. In retrospective study, Weevaluated simultaneous immunohistochemical expression of these two molecules in 92 cases who were treated surgically byCholecystectomy with or without lymph node dissection.NormalGall bladder mucosa reacted strongly with ECAD and weakly with AMFR. With increasing dedifferentiation of the tumour, reversal manifested- more aggressive grades showed varied expression in comparison to its less aggressive type. Gastric3 adenocarcinoma show weak ECAD (83% vs. 35%) and more AMFR ( 93.% vs. 35%)expression in comparison to Grade1.Weak ECAD and strong AMFR was also associated with increase in depth of tumour invasion. As ECAD and AMFR is at least partially responsible for varying histologic grade and behavioral pattern of Gall bladder adenocarcinoma, simultaneous evaluation of both parameters is helpful to understand pathway of progression of such cancer cell.
Authors and Affiliations
Dr. Debashis Roy Burman, Dr. Dibyendu , Goutam2
Keywords
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- EP ID EP361439
- DOI 10.9790/0853-1702041117
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