A RANDOMIZED PLACEBO CONTROLLED STUDY OF PREOPERATIVE PREGABALIN ON POSTCHOLECYSTECTOMY PAIN RELIEF
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 7
Abstract
There are studies that have demonstrated the role of pregabalin as a pre-emptic analgesic in the multimodal therapy for acute postoperative pain management. However, its use in more painful operative procedures like open cholecystectomy are limited and hence the present study was undertaken to evaluate the effectiveness of a single dose of preoperative oral pregabalin in attenuating the postoperative pain. In this randomized, controlled, prospective and double blind study, 80 patients (ASA I & II, aged 18-55 years and of both sexes) undergoing open cholecystectomy under GA were divided into two equal groups (n=40 each) to receive either oral pregabalin 150mg or placebo 1 hour before the surgery. Intraoperative hemodynamic variables, postoperative VAS scores, sedation scores, analgesic free time intervals, total dose of rescue analgesic, side effects etc. were recorded and compared for the first 24 hours postoperatively. VAS score distribution in the first 24 hours were significantly lower in the pregabalin group than the control group (P<0.05). The analgesia free time interval was longer and the number of rescue analgesic(inj. tramadol 50mg) was lesser in the pregabalin 150mg (P<.05). Preoperative pregabalin 150 mg administered 1 hour prior to surgery attenuates the postoperative pain thereby reducing opioid consumption.
Authors and Affiliations
Upendra Singh, Hemjit Singh, Pratima Khoyumthem, Surmila Khoirom, Thoibahenba Singh, Javan N. G
Keywords
Related Articles
- EP ID EP158931
- DOI 10.14260/jemds/2014/2027
- Views 77
- Downloads 0
ANATOMY OF RECURRENT LARYNGEAL NERVE IN THYROIDECTOMY
BACKGROUND Thyroid surgeries have been through tremendous evolution to make it a safe procedure. Thyroid surgery can today be performed with practically no added mortality other than the risk of general anaesthesia. A li...
EVALUATION OF CLINICALLY PALPABLE BREAST LUMPS WITH DIGITAL MAMMOGRAPHY, SONOGRAPHY AND FNAC: CASE STUDY
Breast cancer is the second leading cause of cancer deaths in women today (After lung cancer) and is the most common cancer among women, excluding non-invasive non-melanoma skin cancers. Worldwide, breast canc...
COMPARATIVE STUDY BETWEEN LIGHTWEIGHT MESH AND STANDARD PROLENE MESH IN LICHTENSTEIN HERNIA REPAIR
BACKGROUND Inguinal hernia repair is the most frequently performed operation in any general surgical unit. Reports on the outcome of inguinal hernia surgery show that recurrence rate 5 years after operation can vary from...
A STUDY ON TONSIL CORE CULTURE IN CHRONIC AND RECURRENT TONSILLITIS
BACKGROUND Palatine tonsils are the components of Mucosa Associated Lymphoid Tissue (MALT) of pharynx. Embryologically, they develop from second branchial arch and play an important role in immune system. These are lined...
COMPARISON OF RIPASA AND ALVARADO SCORING SYSTEM IN ACUTE APPENDICITIS- A DESCRIPTIVE STUDY
BACKGROUND Acute appendicitis is the most common cause of an acute abdomen requiring surgery with a lifetime risk of about 7%. Even with recent advances in imaging modalities, considerable morbidity continues to be assoc...