A Randomized Trial Comparing 600mg With 200mg Of Mifepristone Followed By Oral Misoprostol For Termination Of Early Pregnancy
Journal Title: National Journal of Research in Community Medicine - Year 2015, Vol 4, Issue 3
Abstract
Background: Mifepristone followed by prostaglandin analogue is a common method used for medical abortion. Objective: To compare the abortifacient efficacy of 600mg mifepristone followed by 400ug of misoprostol With 200mg mifepristone followed by 400ug of misoprostol. Methodology: It was a randomized interventional study done at the Department of Obstetrics and Gynecology, SV medical college, Tirupathi. Participants were 200 women seeking termination of pregnancy of 49 days gestational age or less. Among them 100 women were randomly assigned to receive 600mg of mifepristone followed by 400ug oral misoprostol after 48hours and another 100 women were given 200mg mifepristone followed by 400ug oral misoprostol after 48hours. The outcomes measured were complete abortion rate, induction-abortion interval and complications. Results: Complete abortion rate was not statistically different in both the groups. Complications also were not significantly different. Induction abortion interval was more in the 200mg group. Conclusion: For the termination of early pregnancy(≤49days gestational age), 200mg mifepristone followed by 4ooug misoprostol has equal efficacy as 600mg mifepristone followed by 4ooug misoprostol.
Authors and Affiliations
Lakshmi Narayanamma V. , Indira I. , Bharathi T. , Guruprasad G.
Keywords
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